The Collaborative Cross mouse model for dissecting genetic susceptibility to infectious diseases

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Hanifa Abu Toamih AtamniFuad A Iraqi

Abstract

Infectious diseases, also known as communicable diseases, refer to a full range of maladies caused by pathogen invasion to the host body. Host response towards an infectious pathogen varies between individuals, and can be defined by responses from asymptomatic to lethal. Host response to infectious pathogens is considered as a complex trait controlled by gene-gene (host-pathogen) and gene-environment interactions, leading to the extensive phenotypic variations between individuals. With the advancement of the human genome mapping approaches and tools, various genome-wide association studies (GWAS) were performed, aimed at mapping the genetic basis underlying host susceptibility towards infectious pathogens. In parallel, immense efforts were invested in enhancing the genetic mapping resolution and gene-cloning efficacy, using advanced mouse models including advanced intercross lines; outbred populations; consomic, congenic; and recombinant inbred lines. Notwithstanding the evident advances achieved using these mouse models, the genetic diversity was low and quantitative trait loci (QTL) mapping resolution was inadequate. Consequently, the Collaborative Cross (CC) mouse model was established by full-reciprocal mating of eight dive...Continue Reading

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Citations

Mar 13, 2019·G3 : Genes - Genomes - Genetics·John R ShorterFernando Pardo-Manuel de Villena
Apr 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aline de ContiIgor P Pogribny
Oct 3, 2020·Trends in Microbiology·Jeffrey S BourgeoisDennis C Ko
Jul 27, 2021·The Lancet. Respiratory Medicine·Jeremy R BeitlerCarolyn S Calfee

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Methods Mentioned

BETA
exome sequencing
genotyping
dissect
dissection
medical procedure
gene knockout

Software Mentioned

Perio3

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