The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

Ocular Immunology and Inflammation
Rupesh AgrawalVishali Gupta

Abstract

To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

References

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Citations

Nov 26, 2019·Ocular Immunology and Inflammation·Ilaria TestiVishali Gupta
Apr 7, 2020·Ocular Immunology and Inflammation·Rupesh AgrawalVishali Gupta
Apr 23, 2020·Ocular Immunology and Inflammation·Dinesh Visva GunasekeranUNKNOWN Collaborative Ocular Tuberculosis Study (COTS) Group
Sep 8, 2019·Journal of Ophthalmic Inflammation and Infection·Sudha K GaneshSridharan Sudharshan
Aug 23, 2020·Indian Journal of Ophthalmology·Ashish MarkanAniruddha Agarwal
Aug 14, 2019·Ocular Immunology and Inflammation·Ankush KawaliRohit Shetty
Aug 23, 2020·Indian Journal of Ophthalmology·Ankush A KawaliBhujang Shetty
Aug 23, 2020·Indian Journal of Ophthalmology·Ilaria TestiVishali Gupta
Sep 19, 2020·Ocular Immunology and Inflammation·Jordan L MitchellDanièlle A Gunn-Moore
Sep 26, 2020·Ocular Immunology and Inflammation·Aniruddha AgarwalVishali Gupta
Jan 21, 2021·The British Journal of Ophthalmology·Alessandro MarcheseGiuseppe Casalino
Jan 30, 2021·Asia-Pacific Journal of Ophthalmology·Anamika PatelSoumyava Basu
Nov 18, 2020·Tuberculosis·Rupesh AgrawalCarlos Pavesio
Feb 3, 2021·American Journal of Ophthalmology·Aniruddha AgarwalVishali Gupta
Apr 13, 2021·American Journal of Ophthalmology·UNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Nov 5, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Dong Hyun LeeMin Kim
Feb 4, 2022·Ocular Immunology and Inflammation·M BazewiczF Willermain

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