The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis.

Ocular Immunology and Inflammation
Rupesh AgrawalVishali Gupta

Abstract

Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP.Methods: Multicentre retrospective analysis.Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP.Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.

References

Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
May 9, 2007·International Ophthalmology·Luca CiminoLuigi Boiardi
Nov 22, 2007·Survey of Ophthalmology·Vishali GuptaNarsing A Rao
Nov 23, 2007·The New England Journal of Medicine·Rui WangJeffrey M Drazen
Mar 18, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Wesley Ribeiro CamposSilvana Spindola de Miranda
Aug 19, 2008·Journal of Pediatric Ophthalmology and Strabismus·Alexander SprattAnthony J Vivian
Aug 19, 2008·American Journal of Ophthalmology·Reema BansalSunil Kumar Arora
Oct 29, 2009·Indian Journal of Ophthalmology·Kalpana BabuKrishna R Murthy
Jul 2, 2011·The British Journal of Ophthalmology·Marcus AngSoon-Phaik Chee
Jan 15, 2014·Ocular Immunology and Inflammation·E JakobF Mackensen
Jun 3, 2014·Korean Journal of Ophthalmology : KJO·Seong Joon AhnKyu Hyung Park
Sep 7, 2014·International Ophthalmology·Sana KhochtaliMoncef Khairallah
Mar 15, 2015·The Journal of Infectious Diseases·Andrea PantojaClaudia M Denkinger
Jul 19, 2015·The British Journal of Ophthalmology·Rupesh AgrawalCarlos E Pavesio
Jan 27, 2016·Open Forum Infectious Diseases·Marjorie M ConantPatricia DeMarais
Mar 13, 2016·Survey of Ophthalmology·Ae Ra KeeRupesh Agrawal
Jun 3, 2016·Journal of Clinical Microbiology·Stefania ZanettiAntonio Pinna
Nov 7, 2016·The British Journal of Ophthalmology·Marcus Ang, Soon-Phaik Chee
Nov 14, 2016·Microbiology Spectrum·Daniel M Albert, Meisha L Raven
Oct 25, 2017·Annals of Medicine and Surgery·M Shahidatul-AdhaH Adil
Oct 28, 2017·JAMA Ophthalmology·Rupesh AgrawalUNKNOWN Collaborative Ocular Tuberculosis Study (COTS)–1 Study Group
Dec 6, 2017·Journal of Ophthalmic Inflammation and Infection·Erika Marie DamatoPhilip Ian Murray
Jan 11, 2018·International Ophthalmology·Awad Al-QarniAhmed M Abu El-Asrar
Aug 19, 2018·Investigative Ophthalmology & Visual Science·Rupesh AgrawalUNKNOWN Collaborative Ocular Tuberculosis Study Group

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Citations

May 19, 2021·Ocular Immunology and Inflammation·Sarah TouhamiBahram Bodaghi

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