The Collaborative Randomised Amnioinfusion for Meconium Project (CRAMP): 1. South Africa

British Journal of Obstetrics and Gynaecology
G J HofmeyrK Mahomed

Abstract

To evaluate transcervical amnioinfusion for meconium stained amniotic fluid during labout. Multicentre randomised controlled trial. Four urban academic hospitals in South Africa. Obstetric surveillance included the use of electronic fetal heart rate monitoring in most cases. Women in labour at term with moderate or thick meconium staining of the amniotic fluid. Transcervical amnioinfusion of 800 mL saline at 15 mL per minute, followed by a maintenance infusion at 3 mL per minute. The control group received routine care. Blinding of the intervention was not possible. Caesarean section, meconium aspiration syndrome and perinatal mortality. Caesarean section rates were similar (amnioinfusion group 70/167 vs control group 68/159; RR 0.98, 95% CI 0.76-1.26). The incidence of meconium aspiration syndrome was lower than expected on the basis of previous studies (4/162 vs 6/163; RR 0.67, 95% CI 0.19-2.33). There were no perinatal deaths. There were no significant differences between any of the subsidiary outcomes. This study concurred with three previous trials which found no effect of amnioinfusion for meconium-stained amniotic fluid on caesarean section rate, though the pooled data from all identified trials to date show a significan...Continue Reading

References

Jul 1, 1992·American Journal of Obstetrics and Gynecology·C J MacriR H Paul
Jun 1, 1992·British Journal of Obstetrics and Gynaecology·G J Hofmeyr
Jan 11, 1992·American Journal of Obstetrics and Gynecology·V L Katz, W A Bowes
Apr 1, 1991·Anesthesia and Analgesia·D A DragichK Wenstrom
Sep 1, 1989·American Journal of Obstetrics and Gynecology·Y SadovskyR H Petrie
Mar 15, 1985·American Journal of Obstetrics and Gynecology·R O DavisJ F Huddleston
Feb 1, 1994·American Journal of Obstetrics and Gynecology·K D WenstromS S Grant
Oct 1, 1994·American Journal of Obstetrics and Gynecology·N L EriksenV M Parisi
Oct 1, 1994·American Journal of Obstetrics and Gynecology·C Y SpongM G Ross
Feb 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G J HofmeyrM de Jager
Jul 1, 1996·Zeitschrift für Geburtshilfe und Neonatologie·P Groneck, C P Speer
Nov 1, 1996·The Australian & New Zealand Journal of Obstetrics & Gynaecology·K J UrbaniakK M Townend

❮ Previous
Next ❯

Citations

Oct 18, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A PuertasJ A Miranda
Nov 7, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·László HalvaxTibor Ertl
May 17, 2000·Current Opinion in Obstetrics & Gynecology·G J Hofmeyr
Dec 16, 1998·British Journal of Obstetrics and Gynaecology·K M Graham
Oct 13, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J-L Chabernaud
Oct 20, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A CheminS Cantagrel
Mar 24, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·H XuW D Fraser
Aug 25, 2004·Clinics in Perinatology·Steven L GelfandMichele C Walsh
Mar 21, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A K DasB Samanta
Aug 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Gowri Dorairajan, S Soundararaghavan
Jan 24, 2014·The Cochrane Database of Systematic Reviews·G Justus HofmeyrAhizechukwu C Eke
May 17, 2018·The Cochrane Database of Systematic Reviews·Elizabeth R CluettAnna Cuthbert
Feb 15, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Asmita Muthal RathorReva Tripathi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Obstetrics and Gynaecology
K MahomedA M Gulmezoglu
BJOG : an International Journal of Obstetrics and Gynaecology
Asmita Muthal RathorReva Tripathi
Indian Journal of Pediatrics
Mini SoodM M A Faridi
European Journal of Obstetrics, Gynecology, and Reproductive Biology
D V SurbekW Holzgreve
© 2022 Meta ULC. All rights reserved