The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

International Journal of Oncology
Maria C MelanderNiels Behrendt

Abstract

The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.

References

Jan 1, 1992·Connective Tissue Research·A MaroudasE Gilav
Jun 1, 1990·Molecular and Cellular Biology·C M IsackeI S Trowbridge
Oct 1, 1980·Annals of the Rheumatic Diseases·A MaroudasM F Venn
Aug 30, 1996·The Journal of Biological Chemistry·K WuL A Lasky
Nov 15, 1997·Cancer·G R Mundy
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·P SaftigK von Figura
Jan 15, 2000·The Journal of Biological Chemistry·N BehrendtK Danø
Aug 19, 2000·Science·B St CroixK W Kinzler
Mar 30, 2001·Periodontology 2000·J Sodek, M D McKee
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V EvertsW Beertsen
Sep 12, 2002·Biochimica Et Biophysica Acta·Lucy East, Clare M Isacke
Oct 26, 2002·The Journal of Biological Chemistry·Lucy EastClare M Isacke
Dec 12, 2002·Micron : the International Research and Review Journal for Microscopy·V OttaniM Raspanti
Apr 2, 2003·The Journal of Cell Biology·Lars H EngelholmThomas H Bugge
Sep 4, 2003·The Journal of Cell Biology·Justin SturgeClare M Isacke
Dec 31, 2003·Osteoarthritis and Cartilage·M J HowardC M Isacke
Jan 20, 2004·Experimental Cell Research·Lars KjøllerNiels Behrendt
Apr 9, 2005·The Journal of Biological Chemistry·Emily K ThomasPeng Liang
May 4, 2005·Current Neurology and Neuroscience Reports·Roger StuppMonika E Hegi
Jan 31, 2006·The Biochemical Journal·Catherine E NapperMaureen E Taylor
Feb 3, 2006·The Journal of Biological Chemistry·Jasminka BoskovicOscar Llorca
Apr 19, 2006·European Journal of Immunology·Luisa Martinez-PomaresSiamon Gordon
Sep 9, 2006·The Journal of Biological Chemistry·Keiichi InoueShigeyoshi Itohara
Sep 20, 2006·Genes & Development·Kevin HotaryStephen J Weiss
Dec 5, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Birgit Leitinger, Erhard Hohenester
Dec 14, 2006·Histopathology·H A HonardoustL Häkkinen
Dec 26, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jay SulekThomas H Bugge
May 24, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ivana MalovicPeter A G McCourt
Jun 29, 2007·Journal of Leukocyte Biology·Justin SturgeClare M Isacke
Jul 11, 2007·Molecular and Cellular Biology·Rebecca A Wagenaar-MillerKenn Holmbeck
Oct 24, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Giovanna M D'Abaco, Andrew H Kaye
Jan 15, 2008·Cellular and Molecular Life Sciences : CMLS·O Llorca

❮ Previous
Next ❯

Citations

Nov 19, 2015·The Journal of Pathology·Justin Sturge
May 25, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael J PodolskyKamran Atabai
May 14, 2020·Journal of Cellular Physiology·XiangHua HanPeter C Brooks
Feb 27, 2020·Cellular and Molecular Life Sciences : CMLS·Henrik J JürgensenDaniel H Madsen
Jun 30, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Daniel O VelezStephanie I Fraley
Dec 7, 2016·Journal of Cellular Biochemistry·Sara SprangersVincent Everts
Jun 29, 2016·Cell and Tissue Research·Nuno Miranda Coelho, Christopher A McCulloch
Nov 25, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Andrew J Ford, Padmavathy Rajagopalan
Dec 23, 2020·International Journal of Molecular Sciences·Andrea SoltysovaBozena Smolkova
Jun 5, 2021·Tissue Engineering. Part B, Reviews·Yuan-Hao XieWei-Liang Shen
May 21, 2021·Analytical Cellular Pathology (Amsterdam)·Lanlan LiWeiping Lu
Dec 16, 2020·Blood Reviews·Ishnoor SidhuAnilkumar Gopalakrishnapillai
Oct 7, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Johanna TüshausStefan F Lichtenthaler

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
protein folding
glycosylation
Gene knock-out
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.