The combination of abdominal obesity and high-sensitivity C-reactive protein predicts new-onset hypertension in the general Japanese population: the Tanno-Sobetsu study

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Mizue FujiiMitsuru Mori

Abstract

The aim of this study was to examine whether the combination of abdominal obesity and high serum levels of high-sensitivity C-reactive protein (hsCRP) improves the prediction of new-onset hypertension in the general Japanese population. Participants in the Tanno-Sobetsu study, a prospective cohort study, were enrolled. Of 1516 subjects aged 30 years or older in 2002, those with hypertension or abnormal hsCRP levels were excluded, and the remaining 705 subjects were included in the present analyses. Abdominal obesity (AO) and high hsCRP levels were defined by the Japanese criteria of waist circumference and median hsCRP values, respectively. Subjects were followed up on for a maximum of 4.5 years, and the hazard ratio (HR) for new-onset hypertension was calculated using the Cox proportional hazard model. The HR for new-onset hypertension after adjustment for age, sex, fasting plasma glucose, alcohol intake, smoking, treatment for dyslipidemia and high normal blood pressure at baseline was significantly higher in the group with AO and high hsCRP (HR=1.44, 95% CI: 1.00-2.07) compared with the reference group, a group with no AO and low hsCRP; AO alone or high hsCRP alone was not associated with a significant increase in the HR. Si...Continue Reading

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Citations

Feb 19, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gerard Cybulski, Wiktor Niewiadomski
Jan 23, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Paweł KrzesińskiAndrzej Skrobowski
Nov 13, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Szu-Chia ChenHo-Ming Su
Jul 1, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Long ZhouLiancheng Zhao
Oct 21, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jessica E Middlemiss, Carmel M McEniery
Mar 10, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Li GangDu Juan
Jan 20, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shingo HosooKozo Nakamura
Jan 20, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi ItohMasami Tanaka
Oct 27, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·William Rodrigues TebarDiego Giulliano Destro Christofaro
Oct 6, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Massimo LeggioAndrea Mazza

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