The combination of conjugated linoleic acid (CLA) and extra virgin olive oil increases mitochondrial and body metabolism and prevents CLA-associated insulin resistance and liver hypertrophy in C57Bl/6 mice

The Journal of Nutritional Biochemistry
Flavia BaraldiLuciane C Alberici

Abstract

Clinical conditions associated with obesity can be improved by daily intake of conjugated linoleic acid (CLA) or extra virgin olive oil (EVOO). Here we investigated whether dietary supplementation with CLA and EVOO, either alone or in combination, changes body metabolism associated with mitochondrial energetics. Male C57Bl/6 mice were divided into one of four groups: CLA (1:1 cis-9, trans-11:trans-10, cis-12; 18:2 isomers), EVOO, CLA plus EVOO or control (linoleic acid). Each mouse received 3 g/kg body weight of the stated oil by gavage on alternating days for 60 days. Dietary supplementation with CLA, alone or in combination with EVOO: (a) reduced the white adipose tissue gain; (b) increased body VO2 consumption, VCO2 production and energy expenditure; (c) elevated uncoupling protein (UCP)-2 expression and UCP activity in isolated liver mitochondria. This organelle, when energized with NAD(+)-linked substrates, produced high amounts of H2O2 without inducing oxidative damage. Dietary supplementation with EVOO alone did not change any metabolic parameter, but supplementation with CLA itself promoted insulin resistance and elevated weight, lipid content and acetyl-CoA carboxylase-1 expression in liver. Interestingly, the in vivo ...Continue Reading

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Citations

Nov 7, 2016·BMC Complementary and Alternative Medicine·Madeha N Al-SeeniAbeer M Alnefayee
Nov 1, 2016·Molecular Neurobiology·Carlos Henrique Rocha CatalãoMaria José Alves Rocha
Mar 12, 2019·The Journal of Nutritional Biochemistry·Jose Cordoba-ChaconPapasani V Subbaiah
Aug 20, 2021·Antioxidants & Redox Signaling·Luciane C Alberici, Helena C F Oliveira

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