PMID: 20127037Feb 4, 2010Paper

The combination of exercise training and alpha-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

International Journal of Molecular Medicine
Joon Y ChoDae Y Hwang

Abstract

Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study. Therefore, the purpose of this study was to investigate the effects of combining exercise training with the administration of antioxidants on the pathological phenotype of AD. To accomplish this, non-transgenic mice (Non-Tg) and NSE/APPsw Tg mice were treated with alpha-lipoic acid and treadmill exercised for 16 weeks, after which their brains were evaluated to determine whether any changes in the pathological phenotype-related factors occurred. The results indicated that (i) the combination-applied (COMA) Tg group with exercise training (ET) and alpha-lipoic acid administration (LA) showed ameliorated spatial learning and memory compared to the sedentary (SED)-Tg and single-treatment groups; (ii) there were no differences in the level of Abeta-42 peptides across groups; (iii) the level of glucose transporter-1 and brain-derived neurotrophic factor proteins were highly increased in the COMA group, (iv) ET and LA did not induce a synergistic effect on the expression of heat shock protein-70 and apoptotic proteins including Bax and caspase-3; (v) the levels of SOD-1 and CAT suppress...Continue Reading

Citations

Apr 27, 2012·Inflammopharmacology·G Joseph BroussardGloria J Klapstein
Oct 21, 2016·Appetite·Krishnendu Ray
Feb 27, 2018·The Physician and Sportsmedicine·Paul D LoprinziPamela Ponce
Aug 12, 2014·Diabetology & Metabolic Syndrome·Marilia Brito Gomes, Carlos Antonio Negrato
Jun 22, 2016·Brain Pathology·Susana CardosoPaula I Moreira
May 20, 2019·Journal of Alzheimer's Disease : JAD·Hugo McGurranNicholas T Bott
Jun 23, 2019·Journal of Alzheimer's Disease : JAD·Elizabeth Kurudamannil George, P Hemachandra Reddy
Jan 29, 2020·Behavioural Brain Research·Thiago Medeiros da Costa DanieleVeralice Meireles Sales de Bruin
Jun 3, 2021·Aesthetic Plastic Surgery·Elif Seda KeskinDogan Çakan
Aug 3, 2021·Experimental Gerontology·Francisco Sérgio Lopes Vasconcelos-FilhoVânia Marilande Ceccatto

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