The combination of fecal calprotectin with ESR, CRP and albumin discriminates more accurately children with Crohn's disease

Advances in Medical Sciences
Urszula DanilukDariusz Marek Lebensztejn

Abstract

Increased fecal calprotectin is a sensitive marker of various types of intestinal inflammation. We investigated correlations between high fecal calprotectin concentration and serum inflammatory markers in children with different intestinal diseases with diarrhea with/without blood and/or abdominal pain, to test whether the combination of these markers can differentiate potential patients with inflammatory bowel disease. The study included 128 children with high fecal calprotectin concentration (>150ug/g) and symptoms suggesting bowel disorders, hospitalized in the years 2013- 2015. Twenty-six (20%) patients were diagnosed with Crohn's disease, 55 (43%) with ulcerative colitis, 32 (25%) with intestinal infection and 15 (12%) with food protein induced proctocolitis. Significantly increased inflammatory markers were detected in children with inflammatory bowel disease, with a correlation between calprotectin and erythrocyte sedimentation rate - ESR (R = 0.53), mean corpuscular volume - MCV (R=-0.64), red blood cell distribution width (R = 0.56), albumin (R = -0.52), hemoglobin (R = -0.53) only in Crohn's disease patients. To discriminate Crohn's disease patients from patients with intestinal infection and patients with food protei...Continue Reading

Citations

Feb 2, 2021·Journal of Inflammation Research·Paulina Krawiec, Elżbieta Pac-Kożuchowska
Jun 3, 2021·Medicina·Piotr JakimiecUrszula Daniluk
Jul 10, 2021·Immunology·Egle Kvedaraite
Dec 17, 2021·BMC Gastroenterology·Xiao-Fu ChenXie-Lin Huang
Aug 27, 2021·Journal of Pediatric Gastroenterology and Nutrition·Chenthan KrishnakumarSubra Kugathasan

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