PMID: 8601041Sep 1, 1995Paper

The combination of mannitol and albumin in the priming solution reduces positive intraoperative fluid balance during cardiopulmonary bypass

Perfusion
I R Jenkins, A P Curtis

Abstract

During cardiopulmonary bypass (CPB) an adequate reservoir volume is maintained by the addition of crystalloid, colloid or packed cells to the reservoir. This volume contributes to the overall perioperative positive fluid balance. We studied the effect of the preoperative addition of either 75 g albumin, or 50 g mannitol followed by 50 g at commencement of rewarming or both of the above to a bypass circuit prime of lactated Ringer's solution (LR) on intraoperative fluid balance, postoperative indices of oxygenation and time to extubation. The study was a prospective, randomized, single-blinded controlled trial of 103 patients undergoing cardiac surgery requiring CPB. There was a large and highly significant reduction in volume of fluid added to the reservoir during CPB (2137 +/- 1499 ml versus 144 +/- 230 ml), the fluid balance during bypass, including prime volume (3236 +/- 650 ml versus 5876 +/- 1465 ml), and perioperative fluid balance (4470 +/- 936 ml versus 7023 +/- 1760 ml) in the group receiving both mannitol and albumin in the pump prime compared with the group receiving only lactated Ringer's solution. There were no differences between the groups with respect to both measured indices of oxygenation measured on return to...Continue Reading

Citations

Dec 4, 2002·Artificial Organs·Masanori FujitaTadaaki Maehara
Aug 17, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Matthias LangeMartin Westphal
Sep 15, 2004·Journal of Cardiothoracic and Vascular Anesthesia·James A RussellMahlon M Wilkes
Aug 26, 1998·Journal of Cardiothoracic and Vascular Anesthesia·J AukermanR Mosca
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Philippe Van der LindenDavid Faraoni
Dec 17, 2002·Critical Care Medicine·Lori Q RieggerEdward L Bove

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