Dec 23, 1978

The combination of methyldopa with pindolol in the treatment of hypertension (author's transl)

MMW, Münchener medizinische Wochenschrift
I Szám, B Pálossy


32 patients with moderate or severe hypertension (16 men and 16 women, aged 32--75 years) were treated with alpha-methyldopa (daily dose: 750 mg) + placebo for 2 weeks, then with alpha-methyldopa + pindolol (15--45 mg daily) for 12 weeks. These patients had been under alpha-methyldopa monotherapy before the trial with unsatisfactory results. The simultaneous administration of alpha-methyldopa and pindolol considerably decreased the systolic and diastolic blood pressure, both sitting and standing, and the heart rate. The combination of methyldopa and pindolol was significantly more effective than methyldopa alone.

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Mentioned in this Paper

Diastolic Blood Pressure Measurement
Diastolic Blood Pressure
Methyldopa, centrally acting adntiadrenergic agents
Hypertensive Disease
Drug Augmentation

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