The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice

Peptides
S G BarretoGino T P Saccone

Abstract

Both galanin and substance P have been separately implicated in the pathogenesis of acute pancreatitis. We compared the efficacy of the combination of the galanin antagonist galantide and the neurokinin-1 receptor antagonist L703,606 with that of either alone in the treatment of acute pancreatitis. Acute pancreatitis was induced in mice with 7-hourly caerulein injections. Galantide was co-administered with each caerulein injection commencing with the first injection (prophylactic) or 2h after the first injection (therapeutic). L703,606 was administered either 30 min before (prophylactic), or 2h after the first caerulein injection (therapeutic). Combination of the two agents was also administered. Control groups received galantide, L703,606, or saline, without caerulein. Pancreata were harvested for histological examination and estimation of myeloperoxidase activity. Plasma amylase activity was measured. Prophylactic and therapeutic administration of galantide reduced the hyperamylasemia by 37% and 30% respectively whereas only prophylactic L703,606 reduced hyperamylasemia (by 34%). Prophylactic administration of the combined antagonists reduced the hyperamylasemia by 44%. In contrast, therapeutic administration of the combinati...Continue Reading

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Citations

Apr 15, 2011·Annals of Surgery·Savio G Barreto, Nilesh H Doctor
Jan 22, 2011·World Journal of Gastroenterology : WJG·Nilesh DoctorSavio G Barreto
Feb 20, 2013·Journal of Cancer Research and Clinical Oncology·Kiyoshi MisawaHiroyuki Mineta
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Jul 29, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Savio G BarretoGino T P Saccone
Feb 10, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S G BarretoG T P Saccone

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