The combination of tacrolimus and entecavir improves the remission of HBV-associated glomerulonephritis without enhancing viral replication

Clinica Chimica Acta; International Journal of Clinical Chemistry
Lifen WangWei Shi

Abstract

Tacrolimus inhibits hepatitis B virus entry into hepatocytes through targeting the HBV receptor, sodium taurocholate cotransporting polypeptide. This study was performed to evaluate the efficacy and safety of Tacrolimus combined with entecavir antiviral therapy for HBV-associated glomerulonephritis patients with biopsy-proven membranous nephropathy. A cohort of 42 patients was enrolled in this retrospective study. Twenty-three patients received Tacrolimus (0.05mg/kg/day) in combination entecavir over 24weeks, whereas the other 19 patients only received entecavir monotherapy. The probability of proteinuria remission in the Tacrolimus +entecavir group was 69 and 87% after 12 and 24weeks, whereas was only 26 and 42%, respectively, in the entecavir group. The mean time to partial or complete remission was 18.6weeks in the Tacrolimus +entecavir group and 34.3weeks in the entecavir group (P<0.001). A decrease in the HBV DNA titer was observed in all patients with active HBV replication. None of the HBV carriers in the Tacrolimus +entecavir group showed evidence of HBV reactivation. The serum creatinine and alanine aminotransferase levels remained stable in both groups. The Tacrolimus target trough concentration was 5-10ng/ml. Tacroli...Continue Reading

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Citations

Oct 16, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Lifen WangZhiming Ye
Dec 22, 2020·Frontiers in Medicine·Gabriella Moroni, Claudio Ponticelli

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