The combination of targeted and systematic prostate biopsies is the best protocol for the detection of clinically significant prostate cancer

Scandinavian Journal of Urology
Alexandre FourcadeAntoine Valeri

Abstract

Compared with standard systematic transrectal ultrasound (TRUS)-guided biopsies (SBx), targeted biopsies (TBx) using magnetic resonance imaging (MRI)/TRUS fusion could increase the detection of clinically significant prostate cancer (PCa-s) and reduce non-significant PCa (PCa-ns). This study aimed to compare the performance of the two approaches. A prospective, single-center study was conducted on all consecutive patients with PCa suspicion who underwent prebiopsy multiparametric MRI (mpMRI) using the Prostate Imaging Reporting and Data System (PI-RADS). All patients underwent mpMRI/TRUS fusion TBx (two to four cores/target) using UroStation™ (Koelis, Grenoble, France) and SBx (10-12 cores) during the same session. PCa-s was defined as a maximal positive core length ≥4 mm or Gleason score ≥7. The study included 191 patients (at least one suspicious lesion: PI-RADS ≥3). PCa was detected in 55.5% (106/191) of the cases. The overall PCa detection rate and the PCa-s detection rate were not significantly higher in TBx alone versus SBx (44.5% vs 46.1%, p = .7, and 38.2% vs 33.5%, p = .2, respectively). Combined TBx and SBx diagnosed significantly more PCa-s than SBx alone (45% vs 33.5%, p = .02). PCa-s was detected only by TBx in 12%...Continue Reading

Associated Clinical Trials

References

Nov 11, 2009·Nature Reviews. Urology·Nicolas B Delongchamps, Gabriel P Haas
Feb 11, 2012·European Radiology·Jelle O BarentszUNKNOWN European Society of Urogenital Radiology
Sep 18, 2012·The Journal of Urology·Nicolas Barry DelongchampsFrançois Cornud
Jun 22, 2013·European Urology·Stacy LoebYair Lotan
Dec 3, 2014·The Journal of Urology·Christian ThomasJoachim W Thüroff
Dec 20, 2014·BioMed Research International·Philippe PuechLaurent Lemaitre

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Citations

Mar 28, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Abdullah DemirtaşTürev Demirtaş
Nov 16, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Q VesvalJ Olivier

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