The combination of the load/force balance and the frequency/tidal volume can predict weaning outcome

Intensive Care Medicine
T VassilakopoulosS Zakynthinos

Abstract

To examine whether an appropriately designed combination of an index of ventilatory endurance and the frequency divided by tidal volume ratio (f/VT) provides prognostic information for weaning outcome not offered by any index alone. Prospective study in a multidisciplinary intensive care unit, university hospital. 124 consecutive mechanically ventilated patients. We designed an index of ventilatory endurance (load/force balance) calculated as the mean inspiratory airway pressure (PI) during controlled mechanical ventilation/maximum inspiratory pressure (MIP) [PI equals the triplicate of mean airway pressure (Paw) displayed by the ventilator] and tested its capacity in predicting weaning outcome at 48 h along with f/VT and many other indices in 75 consecutive mechanically ventilated patients ready to wean. A stepwise discriminant function analysis was used to test the performance of appropriately designed index combination. Threshold values of indices and their combination were prospectively validated in another group of 45 consecutive patients. Stepwise discriminant analysis showed that PI/MIP and f/VT were the only indices that remained in the model with the function D=7.628xmean Paw/MIP+0.0158xf/VT-2.374. The cutoff point of ...Continue Reading

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Citations

Dec 1, 2009·Intensive Care Medicine·Leopoldo N SegalStanley B Fiel
Aug 20, 2008·Critical Care : the Official Journal of the Critical Care Forum·Mohamad F El-Khatib, Pierre Bou-Khalil
Apr 2, 2013·Archivos de bronconeumología·Jorge ValenzuelaPablo Cruces
Mar 31, 2009·Journal of Critical Care·Cassiano TeixeiraEubrando Silvestre Oliveira
Dec 6, 2008·Journal of Critical Care·Cassiano TeixeiraJosé da Siva Moreira
Jan 31, 2009·Current Opinion in Critical Care·Scott K Epstein
Nov 21, 2007·Anaesthesia and Intensive Care·I StanopoulosP Argyropoulou

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