The combination of vitamin D deficiency and overweight affects muscle mass and function in older post-menopausal women

Aging Clinical and Experimental Research
Francesca GimiglianoGiovanni Iolascon

Abstract

It has been suggested that overweight and obese individuals have an increased risk to develop vitamin D deficiency, commonly associated with poor muscle performance. The relationship among fat mass, vitamin D status, and skeletal muscle is still debated. To evaluate the effects of the combination of hypovitaminosis D and overweight on muscle mass and strength, and physical performance in post-menopausal women. In this cross-sectional study, we recruited post-menopausal women referring to a physiatric outpatient service for the management of osteoporosis over a 36-month period. We compared four groups: (1) normal weight with hypovitaminosis D; (2) overweight with normal serum 25(OH)D3; (3) overweight with hypovitaminosis D; and (4) normal weight with normal serum 25(OH)D3 (control group). Outcome measures were: appendicular lean mass-to-BMI ratio; hand grip strength; and short physical performance battery. We analysed 368 women (mean aged 67.2 ± 7.8 years): 95 normal weight with hypovitaminosis D, 90 overweight with normal levels of 25(OH)D3, 96 overweight with hypovitaminosis D, and 87 normal weight with normal levels of 25(OH)D3. Overweight women with hypovitaminosis D had a significant risk of reduced muscle mass (OR 5.70; p ...Continue Reading

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Citations

Jul 19, 2018·Minerva gastroenterologica e dietologica·Roberto de SireFranco Scaldaferri
Oct 2, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Vicky Kamwa, Zaki K Hassan-Smith
Nov 9, 2018·Aging Clinical and Experimental Research·Walter VerrusioMauro Cacciafesta
Nov 22, 2019·Aesthetic Plastic Surgery·Luigi LoscoCarlos P Roxo
Jul 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hossam M ShokriAhmed Ghareeb
Feb 18, 2021·American Journal of Physical Medicine & Rehabilitation·Francesco AgostiniStefano Masiero
Apr 22, 2021·International Journal of General Medicine·Jiaxi ZhaoXiaofeng Yu
Aug 18, 2021·The Physician and Sportsmedicine·Seçkin ŞenışıkNevzad Denerel
Oct 26, 2021·Climacteric : the Journal of the International Menopause Society·H ChenS-J Wang

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