The combination oral and nutritional treatment of late-onset diabetes mellitus (CONTROL DM) trial results

Diabetic Medicine : a Journal of the British Diabetic Association
D M ReboussinJ Williamson

Abstract

To examine the effect of short-term improvements in glycaemic control on brachial artery endothelial function as a marker of cardiovascular health. Persons with Type 2 diabetes who were poorly controlled on oral therapy were randomly assigned to monotherapy with repaglinide or combination therapy with repaglinide plus metformin. Brachial artery flow-mediated vasodilation was assessed by ultrasonography at randomization and following 16 weeks of therapy. The primary outcome was change in brachial artery endothelial function from baseline. Comparison of randomized groups was a secondary aim. Eighty-six participants were randomized, and 83 were followed to study completion. Post occlusion brachial artery vasodilation was 3.74% at baseline and 3.82% following 16 weeks of therapy (P = 0.77). The treatment effect was 0.08% (95% CI: -0.48%, 0.64%). No difference was seen between treatment groups (P = 0.69). Overall, A1C was reduced from 8.3% to 7.0%, with a greater reduction in the combination therapy group (from 8.4% to 6.7%) than in the monotherapy group (from 8.3% to 7.3%, p for difference between groups = 0.01). Statistically significant reductions were observed in fasting glucose, and plasminogen activator inhibitor-1. Statistica...Continue Reading

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Citations

May 30, 2009·Diabetes, Obesity & Metabolism·P RaskinUNKNOWN Repaglinide/Metformin Fixed-Dose Combination Study Group
Jun 18, 2009·Diabetes, Obesity & Metabolism·P RaskinUNKNOWN Repaglinide/Metformin Fixed-Dose Combination Study Group
Jan 1, 2009·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Robert Moses
Jan 1, 2010·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Robert G Moses
Jan 1, 2011·Clinical Medicine Insights. Endocrinology and Diabetes·John W Richard, Philip Raskin
Dec 3, 2014·Progress in Cardiovascular Diseases·Yasushi MatsuzawaAmir Lerman
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Jul 25, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Stephen C Bain
May 1, 2010·Expert Review of Endocrinology & Metabolism·Robert G Moses
Nov 5, 2014·Coronary Artery Disease·Yasushi Matsuzawa, Amir Lerman

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