The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly

Endocrinologia Japonica
K HanewK Yoshinaga

Abstract

The therapeutic efficacy of the combination of cyproheptadine and bromocriptine was studied in 15 patients with active acromegaly showing incomplete GH suppression in response to bromocriptine therapy alone. The mean basal plasma GH was 31.3 +/- 5.5 micrograms/L, and it decreased to 19.0 +/- 3.9 micrograms/L during the single bromocriptine therapy (10 to 20 mg for 2 to 21 months). When cyproheptadine (12 to 16 mg for 8 to 52 months) was added to bromocriptine therapy, plasma GH decreased further (9.4 +/- 3.0 micrograms/L: vs pretreatment, P less than 0.001; vs bromocriptine treatment, P less than 0.005), and GH normalization was obtained in 8 patients. The plasma somatomedin-C levels in these 8 patients (0.3-1.8 U/ml) were within the normal range during the combination therapy. Plasma GH responses to TRH or GHRH were markedly suppressed in 6 patients during the combination therapy compared to pretreatment or during bromocriptine treatment. In addition, a clear reduction in the tumor size was observed in 4 of 7 previously untreated patients during the combination therapy. In conclusion, cyproheptadine has therapeutic efficacy in acromegalic patients who showed incomplete GH suppression in response to treatment with bromocriptine...Continue Reading

Citations

Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·C B Newman
Dec 1, 1994·The American Journal of the Medical Sciences·A Y Krishna, L S Phillips
Jul 1, 1993·The Journal of Pediatric Endocrinology·H J Quabbe
Apr 14, 2021·Dermatology and Therapy·Chang-Yu Hsieh, Tsen-Fang Tsai

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