PMID: 6777821Jan 1, 1980Paper

The combined action of chemical carcinogens on DNA repair in human cells

Radiation and Environmental Biophysics
F E Ahmed

Abstract

Excision repair was studied in normal human and ataxia telangiectasia (AT) cells proficient in repair of UV and its mimetic chemicals, and in xeroderma pigmentosum group C (XP C) cells (deficient in repair of UV and its mimetics), after treatment with several combinations of chemical carcinogens, by the photolysis of bromodeoxyuridine incorporated into parental DNA during repair. Results indicate that repair was additive in AT, and XP C cells treated with N-acetoxy-2-acetylaminofluorene (AAAF) plus ethyl methanesulfonate (EMS) or methyl methanesulfonate (MMS) indicating that there are different rate limiting steps for removal of both types of damage. Data on the combinations of 4-nitroquinoline 1-oxide (4NQO) plus MMS or EMS are difficult to interpret, but they do not indicate inhibition of DNA repair.

References

May 1, 1979·Photochemistry and Photobiology·F E Ahmed, R B Setlow
Feb 1, 1976·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R B SetlowJ D Regan
Nov 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowW L Carrier
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J D ReganR D Ley
Mar 1, 1970·Biophysical Journal·M M Elkind, C Kamper

Related Concepts

NSC-38297
Tumor Promoters
Base Excision Repair
Ethyl Methanesulfonate
Fibroblasts
Dimethylsulfonate
Photochemistry
Black Light, Ultraviolet
Acetylaminofluorene
4-Nitroquinoline-1-oxide

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