The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China: an 18F-FDG-PET/CT study

Nuclear Medicine Communications
Guobing LiuHongcheng Shi

Abstract

The aim of the study was to investigate the combined effects of serum lipids, BMI, and fatty liver on the liver uptake of fluorine-18 fluorodeoxyglucose ((18)F-FDG). A total of 676 individuals were retrospectively studied. The mean standardized uptake value (SUV) was used to quantify liver (18)F-FDG uptake. Univariate analyses and multivariate regression models identified variables that predicted the mean liver SUV before and after dichotomizing participants into low and high BMI groups. The mean liver SUV (1.831 ± 0.417) differed significantly among nutritional categories (P = 0.005) and degrees of fatty liver (P < 0.001). An increase in mean liver SUV was noted in individuals with mild and moderate fatty liver compared with normal individuals and in overweight individuals compared with underweight individuals, whereas a downward trend was identified in both individuals with severe fatty liver and those who were obese. BMI had the strongest association with severity of fatty liver (r = 0.443, P < 0.001). Triglyceride, HDL, apolipoprotein-A, age, and BMI were independent variables predicting liver SUV mean in the whole population, whereas fatty liver severity presented as an independent variable only in the low BMI population (...Continue Reading

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Citations

Jan 16, 2016·Annals of Nuclear Medicine·Georgia KeramidaA Michael Peters
Mar 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyun-Yeol NamIn Joo Kim
Jan 1, 2020·Journal of Medical Imaging and Radiation Oncology·Su-Faye LeeTom Sutherland
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Aug 28, 2021·Metabolic Syndrome and Related Disorders·Souvik SarkarGuobao Wang

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