The combined effects on neuronal activation and blood-brain barrier permeability of time and n-3 polyunsaturated fatty acids in mice, as measured in vivo using MEMRI.

NeuroImage
Yu-Ting KuoJimmy D Bell

Abstract

N-3 polyunsaturated fatty acids (n-3 PUFA) are known to have cardiovascular and neuroprotective properties in both humans and rodents. Here, we use manganese-enhanced magnetic resonance imaging (MEMRI) to compare the effects of these polyunsaturated fatty acids on the combined effects of neuronal activity and integrity of blood-brain barrier integrity with saturated fatty acids from buttermilk. C57BL/6 mice (4 weeks old) were fed isocaloric diets containing 3% fish oil (3% FO, n=5), 12% fish oil (FO, n=6), 3% buttermilk (3% BM, n=6) or 12% buttermilk (12% BM, n=6) for 6 months. Following metabolic cage analysis these mice were scanned using a standard MEMRI protocol at 28-32 weeks of age. Adult mice aged 28-32 weeks old (RM3, n=5) and 15-16 weeks old (YRM3, n=4) maintained on standard rodent chow were also studied to assess age-related changes in brain barrier systems and neuronal activity. Signal intensity (SI) in the anterior pituitary (AP), arcuate hypothalamic nucleus (ARC), ventromedial hypothalamic nucleus (VMH) and the paraventricular hypothalamic nucleus (PVN) was significantly reduced in young compared to older mice fed standard chow. Furthermore, fish oil supplementation led to a decrease in SI within the ARC and PVN,...Continue Reading

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Citations

Feb 26, 2013·The British Journal of Nutrition·Marianne A YonLucy C Pickavance
Sep 2, 2014·Experimental Gerontology·Moritz GröschelDietmar Basta
Dec 2, 2014·Pharmacology & Therapeutics·Katja SchmitzIrmgard Tegeder
Jan 21, 2014·Neurobiology of Aging·David Bissig, Bruce A Berkowitz
Mar 12, 2015·Brain Structure & Function·Alexander N ComninosWaljit S Dhillo
Jan 12, 2021·Nutritional Neuroscience·Charles-Henri MalbertJacques Delarue

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