PMID: 15374417Nov 1, 1991Paper

The combined insulin and sulfonylurea therapy in diabetes of elderly people

Archives of Gerontology and Geriatrics
A QuatraroD Giugliano

Abstract

The usefulness and safety of the combined insulin-sulfonylurea (gliclazide) therapy were investigated in 70 elderly diabetic patients poorly controlled by insulin alone. More than half (45 diabetics, 64% of total) ameliorated significantly their metabolic control after six months of the combined treatment: not only the glycemic profile and glycated hemoglobin Alc were significantly decreased, but the daily insulin dose was reduced by approx. 35% (p < 0.01). These positive results in terms of improved glycemic control as well as reduction of daily insulin needs were still present after a mean period of follow-up of 5 years. The good percentage of positive results, the small incidence of hypoglycemic episodes and the consistent reduction of peripheral hyperinsulinism make this intervention (insulin-gliclazide) a safe strategy that can be adopted in a population of elderly diabetics, poorly controlled on insulin alone.

References

Jun 1, 1990·Diabetes Care·R W Stout
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Jul 7, 1962·JAMA : the Journal of the American Medical Association·R A CAMERINI-DAVALOS, A MARBLE

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Citations

Jan 18, 2006·Diabetes & Metabolism·J Doucet

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