The combined serum levels of miR-375 and urokinase plasminogen activator receptor are suggested as diagnostic and prognostic biomarkers in prostate cancer

International Journal of Cancer. Journal International Du Cancer
Sven WachHelge Taubert

Abstract

This study aimed to assess the applicability of miR-375 in combination with the soluble urokinase plasminogen activator receptor (suPAR) protein as a diagnostic and/or prognostic biomarker for prostate cancer (PCa) patients. miR-375 levels by qRT-PCR and suPAR levels by ELISA were evaluated in serum samples from 146 PCa patients, 35 benign prostate hyperplasia (BPH) patients and 18 healthy controls. Antigen levels of suPAR differed between healthy controls and PCa or BPH patients, whereas miR-375 levels differed between PCa and BPH patients or healthy controls (p < 0.001). Additionally, suPAR levels differed between the Gleason sum groups GS = 7 versus GS > 7, with higher levels in the latter group (p = 0.011), and miR-375 levels were higher in the tumor stage group T3-T4 compared with the T1-T2 group (p = 0.039). A high concentration of suPAR was associated with a poor disease-specific survival (DSS; p = 0.039). The combination of suPAR and miR-375 levels identified a patient group possessing high levels for both parameters. This was associated with a poorer 10-year overall survival (OS) and DSS, with a 6.38-fold increased risk of death and a 7.68-fold increased risk of tumor-related death (p = 0.00026 and p = 0.014; univariat...Continue Reading

References

Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F Blasi
Dec 3, 2002·Nature Reviews. Cancer·Robert A Bok, Eric J Small
Feb 3, 2004·Current Pharmaceutical Design·Michael J Duffy
Feb 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahrokh F ShariatKevin M Slawin
Jan 12, 2008·Cancer Immunology, Immunotherapy : CII·S H Beachy, E A Repasky
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Mar 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Matthew N PoyMarkus Stoffel
Apr 1, 2010·Molecular Cancer Research : MCR·Jaroslaw SzczyrbaFriedrich Grässer
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jan C BraseHolger Sültmann
Oct 15, 2010·The Prostate·Kati K WalteringTapio Visakorpi
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Mar 15, 2011·International Journal of Cancer. Journal International Du Cancer·Sven WachBernd Wullich
May 20, 2011·Molecular Cancer Research : MCR·Jaroslaw SzczyrbaFriedrich A Grässer
May 27, 2011·Acta Oncologica·Shahrokh F ShariatAnders Bjartell
Nov 5, 2011·International Journal of Cancer. Journal International Du Cancer·Luke A SelthLisa M Butler
Jan 14, 2012·British Journal of Cancer·R J BryantF C Hamdy
Mar 2, 2012·Molecular Medicine Reports·Xiaoning DaiHuimian Xu
Jun 2, 2012·Methods : a Companion to Methods in Enzymology·Ruprecht KunerDaniela Wuttig
Sep 19, 2012·Genes, Chromosomes & Cancer·Mariska BierkensRenske D M Steenbergen
Dec 5, 2012·The Journal of International Medical Research·Y LiC Hu
Feb 23, 2013·Thyroid : Official Journal of the American Thyroid Association·Matthias DettmerMarina N Nikiforova
Jun 20, 2013·British Journal of Cancer·Y ShenX Xie
Jul 19, 2013·International Journal of Molecular Sciences·Xiaoyi HuangLiang Wang
Jul 19, 2013·Molecular and Cellular Biochemistry·Zhengyan WangWeijing Feng
Oct 30, 2013·International Journal of Cancer. Journal International Du Cancer·Jun-Wei YanXing-Xing He
Feb 20, 2014·Medicinal Research Reviews·Ahmed H MekkawyDavid L Morris
May 31, 2014·BioMed Research International·Andreas DimakakosMichael Koutsilieris
Jun 19, 2014·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Wen LiuDanny R Welch

❮ Previous
Next ❯

Citations

Jul 8, 2016·Journal of Human Genetics·Takashi KinoshitaFei-Fei Liu
Oct 30, 2016·Basic & Clinical Pharmacology & Toxicology·Mari EkmanKarl Swärd
Nov 3, 2016·Nature Reviews. Urology·Annika FendlerKlaus Jung
Dec 21, 2017·BioMed Research International·Jin YanGuoxin Zhang
Sep 5, 2018·Postgraduate Medical Journal·Lamiaa HamieMazen Kurban
Jun 13, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Markus EcksteinUNKNOWN German Prostate Cancer Consortium (DPKK)
Sep 15, 2017·PloS One·Marilesia Ferreira de SouzaIlce Mara de Syllos Cólus
Apr 9, 2020·Epigenomics·Irena AbramovicNino Sincic
Nov 3, 2017·Journal of Cellular Biochemistry·Chun-Jiao SongQian-Nan Ding
Sep 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Taylor D CanadyBrian T Cunningham
Jul 17, 2020·Cancer Management and Research·Christopher J McNallyDeclan J McKenna
Apr 6, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ersagun KaragüzelSerap Özer Yaman
Jan 15, 2021·Cancer Management and Research·Zhuo LiXiao-Ke Hao
Sep 9, 2021·Bioscience Reports·Jiahui WeiJiabao Zhang
Dec 21, 2021·Frontiers in Immunology·Line Jee Hartmann RasmussenJesper Eugen-Olsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.