The combined use of edaravone, diuretics, and nonsteroidal anti-inflammatory drugs caused acute kidney injury in an elderly patient with chronic kidney disease

CEN Case Reports
Guang Jian LiuJian'e Zhang

Abstract

The purpose of this study was to draw attention to the fact that the combined use of edaravone, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs) may lead to acute kidney injury. This study was a case report of acute kidney injury resulting from the combined use of the aforementioned types of drugs. A 77-year-old male patient with chronic kidney disease (third stage) who was treated with a combination of edaravone, diuretics, and NSAIDs showed significantly increased blood urea nitrogen and creatinine. Interestingly, the blood urea nitrogen and creatinine levels returned to pretreatment levels after the medications were stopped. The patient's score on the Naranjo Adverse Drug Reaction Probability Scale was a nine, and the score on the Drug Interaction Probability Scale was a five. For elderly patients with chronic kidney disease, the combined use of edaravone, diuretics, and NSAIDs should be avoided.

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Citations

Jun 7, 2013·Journal of Surgical Technique and Case Report·Suleyman BozkurtHuseyin Kadioglu
Jul 9, 2016·The Annals of Pharmacotherapy·Ryan M RivosecchiSandra L Kane Gill
Mar 24, 2021·Critical Care Clinics·Sandra L Kane-Gill

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