The coming-out of malaria gametocytes.

Journal of Biomedicine & Biotechnology
Andrea Kuehn, Gabriele Pradel

Abstract

The tropical disease malaria, which results in more than one million deaths annually, is caused by protozoan parasites of the genus Plasmodium and transmitted by blood-feeding Anopheline mosquitoes. Parasite transition from the human host to the mosquito vector is mediated by gametocytes, sexual stages that are formed in human erythrocytes, which therefore play a crucial part in the spread of the tropical disease. The uptake by the blood-feeding mosquito triggers important molecular and cellular changes in the gametocytes, thus mediating the rapid adjustment of the parasite from the warm-blooded host to the insect host and subsequently initiating reproduction. The contact with midgut factors triggers gametocyte activation and results in their egress from the enveloping erythrocyte, which then leads to gamete formation and fertilization. This review summarizes recent findings on the role of gametocytes during transmission to the mosquito and particularly focuses on the molecular mechanisms underlying gametocyte activation and emergence from the host erythrocyte during gametogenesis.

References

Jun 5, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R E SindenM E Smalley
Jul 1, 1977·The Journal of Endocrinology·D R Bard, I Lasnitzki
Feb 1, 1977·Parasitology·M E Smalley, R E Sinden
Jan 1, 1991·Experimental Parasitology·F KawamotoR E Sinden
Jan 1, 1990·Annual Review of Microbiology·P Alano, R Carter
Aug 1, 1986·Molecular and Biochemical Parasitology·C J JanseJ P Overdulve
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·F HawkingK Gammage
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·M E SmalleyJ Brown
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·M E Smalley, J Brown
Jan 1, 1981·British Journal of Diseases of the Chest·A G Davison, D W Empey
Aug 1, 1994·The American Journal of Tropical Medicine and Hygiene·J A VaughanJ C Beier
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K P DayD J Kemp
Jun 1, 1996·Molecular and Biochemical Parasitology·K C WilliamsonD C Kaslow
Aug 1, 1996·British Journal of Urology·J M Gil-Vernet
Jun 20, 1998·The Journal of Biological Chemistry·G E GarciaR Rosenberg
Jan 27, 1999·Experimental Parasitology·A LensenR Sauerwein
Apr 1, 2000·Molecular and Biochemical Parasitology·S R Brooks, K C Williamson
Nov 1, 2000·Cell·F A Ramírez-Weber, T B Kornberg
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·B L SalmonD E Goldberg
Feb 27, 2001·Nature Structural Biology·A A Morollo, M J Eck
Feb 19, 2002·Trends in Parasitology·Richard E L PaulVincent Robert
Sep 14, 2002·The Journal of Biological Chemistry·Susanne K MillerBrendan S Crabb
Oct 9, 2002·Nature·Geoff Brumfiel
Oct 9, 2002·Nature·Malcolm J GardnerBart Barrell
Oct 9, 2002·Nature·Laurence FlorensDaniel J Carucci

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Citations

Apr 27, 2010·Medical Microbiology and Immunology·Andrea KuehnGabriele Pradel
Aug 21, 2013·The Journal of Antimicrobial Chemotherapy·Kevin J PeineEric M Bachelder
May 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yachen LiXianghu Wang
Feb 10, 2012·Journal of the Royal Society, Interface·Trushant MajmudarMichael J Shelley
Dec 25, 2012·Malaria Journal·Steven B MwakalingaThomas Lavstsen
Feb 19, 2016·Malaria Journal·Daniel Gonçalves, Patrick Hunziker
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Angelika SturmGeoffrey I McFadden
Sep 7, 2012·International Journal of Medical Microbiology : IJMM·Christine C Wirth, Gabriele Pradel
Jul 28, 2011·Cellular Microbiology·Elena DeligianniInga Siden-Kiamos
May 13, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Adriana Farias SilvaVani Xavier Oliveira
Apr 7, 2015·Molecular and Biochemical Parasitology·Melanie J ShearsGeoffrey I McFadden
May 27, 2015·Experimental Parasitology·Alberto Alonso-MoralesFidel de la Cruz Hernández-Hernández
Nov 30, 2010·International Journal for Parasitology·Shusuke NakazawaYoshimasa Maeno
May 24, 2015·Trends in Parasitology·Ross G DouglasFreddy Frischknecht
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Makoah Nigel AminakeGabriele Pradel
Apr 26, 2016·Cellular Microbiology·Sandra BenninkGabriele Pradel
Jun 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jorge M SantosGunnar R Mair
Jan 13, 2011·Memórias do Instituto Oswaldo Cruz·Cristiana S de MacedoLucia Mendonça-Previato
Mar 18, 2017·Current Opinion in Hematology·Aditi AlagananChetan E Chitnis
Apr 20, 2016·Malaria Journal·Lucy M CarterSarah E Reece
Apr 9, 2017·Cold Spring Harbor Perspectives in Medicine·Sara N Mitchell, Flaminia Catteruccia
Dec 30, 2015·Antimicrobial Agents and Chemotherapy·Maxim I MaronKim C Williamson
Jan 1, 2019·Cellular Microbiology·Klara ObrovaAnn-Kristin Mueller
Aug 21, 2013·Parasitology·Robert A WalkerNicholas C Smith
Apr 4, 2019·Cellular Microbiology·Tomasino PaceAnna Olivieri
Nov 30, 2018·Journal of the Royal Society, Interface·Arshad Kamal, Eric E Keaveny

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Methods Mentioned

BETA
electron microscopy

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