The common ovine Shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type

Journal of Clinical Microbiology
V RamachandranS P Djordjevic

Abstract

Shiga toxin 2 (Stx2) has been reported as the main Shiga toxin associated with human disease. In addition, the Stx2 toxin type can have a profound impact on the degree of tissue damage in animal models. We have characterized the stx(2) subtype of 168 Shiga toxin-producing Escherichia coli (STEC) isolates of which 146 were derived from ovine sources (principally feces and meat) and 22 were isolated from humans. The ovine STEC isolates were of serotypes that have been shown to occur commonly in the gastrointestinal tract of healthy sheep. The major stx(2) subtype in the ovine isolates was shown to be stx(2d-Ount) (119 of 146 [81.5%]) and was predominantly associated with serotypes O75:H(-)/H8/H40, O91:H(-), O123:H(-), O128:H2, and OR:H2. However, 17 of 18 (94.4%) ovine isolates of serotype O5:H(-) possessed a stx(2d-O111/OX3a) subtype. Furthermore, STEC isolates of serotypes commonly found in sheep and recovered from both clinical and nonclinical human infections also contained a stx(2d) (stx(2d-Ount/O111/OX3a)) subtype. These studies suggest that a specific stx(2) subtype(s) associates with serotype and may have important epidemiological implications for tracing sources of E. coli during outbreaks of STEC-associated diseases in ...Continue Reading

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Citations

Feb 27, 2003·Comparative Immunology, Microbiology and Infectious Diseases·K A BettelheimS Zimmermann
Nov 27, 2002·Applied and Environmental Microbiology·Michael A HornitzkySteven P Djordjevic
Apr 27, 2002·Applied and Environmental Microbiology·Nathalie PradelValérie Livrelli
Mar 7, 2006·Applied and Environmental Microbiology·Lutz GeueFranz J Conraths
Oct 19, 2004·Clinical Microbiology Reviews·Saul TziporiHoward Trachtman
Nov 8, 2003·Journal of Clinical Microbiology·Vidiya RamachandranSteven P Djordjevic
Jul 5, 2003·Journal of Clinical Microbiology·T VinayagamoorthyRoger Hodkinson
Aug 9, 2003·Journal of Clinical Microbiology·Kari S GobiusPatricia M Desmarchelier
May 27, 2005·Journal of Applied Microbiology·J G Mainil, G Daube
Oct 30, 2009·Journal of Applied Microbiology·D DöpferA M Urdahl
Jul 9, 2004·International Journal of Food Microbiology·C ZweifelR Stephan
May 5, 2005·FEMS Microbiology Letters·C García-AljaroA R Blanch
Dec 4, 2014·Veterinary Microbiology·Fernando Henrique MartinsJacinta Sanchez Pelayo
Apr 25, 2007·Critical Reviews in Microbiology·Karl A Bettelheim
Apr 3, 2003·Experimental Biology and Medicine·Karl A Bettelheim
Apr 25, 2006·Journal of Food Protection·Irma CaroM Rosario García-Armesto
Jun 13, 2003·Journal of Food Protection·C Zweifel, R Stephan
Jan 5, 2021·Foodborne Pathogens and Disease·Siobhán C McCarthyGeraldine Duffy

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