The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity

European Journal of Human Genetics : EJHG
Raffaella BuzzettiUmberto Di Mario

Abstract

Several genetic variants of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) have been identified, among which Pro12Ala, a missense mutation in exon 2, is highly prevalent in Caucasian populations. Up to now, conflicting results with regard to the association between this mutation and complex traits, such as obesity, insulin sensitivity and Type 2 diabetes, have been reported. We investigated the influence of the Pro12Ala polymorphism of PPAR-gamma2 on insulin sensitivity in a large Italian population sample, n=1215, in whom extensive clinical and biochemical analyses were performed. To estimate the insulin sensitivity status, the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated; in the obese/overweight subjects an oral glucose tolerance test (OGTT) was also performed and the Matsuda insulin sensitivity index (ISI) calculated. The insulin secretion index (homeostasis model assessment of percent beta-cell function, HOMA-beta%) was utilized to evaluate beta-cell function. The effect of the Pro12Ala polymorphism on quantitative variables was tested using multiple linear regression analysis. X12Ala (either Pro12Ala or Ala12Ala) genotype was associated with significantly lower fasting insuli...Continue Reading

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Citations

Dec 16, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·José López-MirandaFrancisco Pérez-Jiménez
Apr 25, 2009·PPAR Research·Weimin He
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Sep 27, 2012·American Journal of Therapeutics·Joselyn RojasValmore Bermúdez
Oct 1, 2014·Journal of Cellular and Molecular Medicine·Qing LiJiang Hong
Mar 22, 2020·Current Diabetes Reports·Pieralice SilviaBuzzetti Raffaella

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