Abstract
Individuals with constitutional trisomy 21 (Down syndrome) are at increased risk of developing acute leukaemias, both of myeloid and lymphoid lineage. Although the cause of leukaemia in Down syndrome (DS) remains unknown, potential candidate genes include the ones on chromosome 21, and in particular AML1, the rearrangement of which in the t(8,21) is associated with the French-American-British (FAB) classification M2 subtype of acute myeloid leukaemia (AML) in the general population and has been described in Down patients with AML-M2. Recently, a new rearrangement involving AML1, the t(12;21), producing the TEL/AML1 hybrid transcript, has been described by molecular analysis as the most recurrent genetic lesion in childhood acute lymphoblastic leukemia (ALL). In order to investigate whether the t(12;21) could give a molecular clue as to the precise basis of the etiologic association between DS and acute lymphoblastic leukemia, we tested a series of 11 consecutive cases of ALL in DS children for the presence of the TEL/AML1 transcript, by RT-PCR analysis. We report absence of the TEL/AML1 rearrangement among the 11 cases tested. This data may be suggestive of alternative pathways involved in the pathogenesis of ALL in children wi...Continue Reading
Citations
Sep 16, 2004·Pediatric Blood & Cancer·Mylène BassalLinda C Stork
Jul 4, 1998·Leukemia Research·M L LohF O Smith
Apr 13, 1999·Cancer Genetics and Cytogenetics·D H SpathasJ M Connor
Mar 22, 2002·The Lancet Oncology·H Hasle
Sep 21, 2000·British Journal of Haematology·B Lange
Sep 25, 2001·Archives of Disease in Childhood·J M ChessellsI M Hann
Nov 1, 2007·Blood·Erik ForestierBertil Johansson
Jan 14, 2009·Blood·Sébastien MalingeJohn D Crispino
Jul 16, 2005·Pediatric Hematology and Oncology·Manuel SteinerUNKNOWN Austrian Berlin-Frankfurt-Münster Group
Mar 18, 2005·Pediatric Hematology and Oncology·Manuel SteinerGeorg Mann
Nov 9, 2001·Leukemia & Lymphoma·F M UckunN Heerema
Feb 2, 2010·Hematology/oncology Clinics of North America·C Michel ZwaanParesh Vyas
Feb 5, 2008·Pediatric Clinics of North America·Michel C ZwaanParesh Vyas
Sep 20, 2008·Pediatric Blood & Cancer·Niketa ShahJohann Hitzler
Oct 24, 2006·British Journal of Haematology·James A Whitlock
Oct 19, 2006·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Natalia DixonSherri Zimmerman
Apr 24, 2004·Cancer Genetics and Cytogenetics·Pornthep Tiensiwakul
May 25, 2004·Oncogene·Ewan R Cameron, James C Neil
Jul 3, 2002·Nature Reviews. Cancer·Nancy A Speck, D Gary Gilliland
Aug 23, 2001·Leukemia·S K MaL C Chan
Apr 18, 2003·Oncogene·A UrenJ A Toretsky
Sep 10, 2004·Leukemia·A AttarbaschiUNKNOWN Austrian Berlin-Frankfurt-Münster cooperative study group
Mar 25, 2014·International Journal of Language & Communication Disorders·Glynis Laws, Amanda Hall
Jun 5, 2019·Blood Advances·Yousif MatloubPaul S Gaynon
Jul 25, 2020·Medicine·Wenjun Liao, Ying Liu