The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants

Nature Communications
Christopher KestenStaffan Persson

Abstract

Microtubules are filamentous structures necessary for cell division, motility and morphology, with dynamics critically regulated by microtubule-associated proteins (MAPs). Here we outline the molecular mechanism by which the MAP, COMPANION OF CELLULOSE SYNTHASE1 (CC1), controls microtubule bundling and dynamics to sustain plant growth under salt stress. CC1 contains an intrinsically disordered N-terminus that links microtubules at evenly distributed points through four conserved hydrophobic regions. By NMR and live cell analyses we reveal that two neighboring residues in the first hydrophobic binding motif are crucial for the microtubule interaction. The microtubule-binding mechanism of CC1 is reminiscent to that of the prominent neuropathology-related protein Tau, indicating evolutionary convergence of MAP functions across animal and plant cells.

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Citations

Oct 16, 2019·Plant Signaling & Behavior·Michel Ruiz RosqueteGeorgia Drakakaki
Nov 19, 2019·The EMBO Journal·Christopher KestenClara Sánchez-Rodríguez
Mar 14, 2020·Annual Review of Plant Biology·Eva van ZelmChrista Testerink
Feb 23, 2020·Annual Review of Plant Biology·Charles T Anderson, Joseph J Kieber
Mar 25, 2020·International Journal of Molecular Sciences·Arndt Wallmann, Christopher Kesten
Nov 22, 2019·Nature Communications·Joseph AthertonCarolyn A Moores
Jun 30, 2019·The New Phytologist·Henrik Buschmann, Agnes Borchers
Jun 4, 2020·International Journal of Molecular Sciences·Ahmed IsmailSherif Sherif
Jul 4, 2020·Annals of Botany·Liu WangIan S Wallace
Nov 3, 2020·International Journal of Biological Macromolecules·Fangmei TanYun Liu
Dec 5, 2020·Scientific Reports·Adriana SavastanoMarkus Zweckstetter
Apr 4, 2021·International Journal of Molecular Sciences·Jianwei LiuChunzhao Zhao
Nov 14, 2020·Carbohydrate Polymers·Holly AllenShundai Li
May 1, 2021·International Journal of Molecular Sciences·Shuangshuang ZhaoPingping Wang
Oct 7, 2021·The Plant Cell·Ying Gu, Carolyn G Rasmussen
Oct 27, 2021·Plant & Cell Physiology·Yingying Zhu, Laigeng Li

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Datasets Mentioned

BETA
PXD009260

Methods Mentioned

BETA
transmission electron microscopy
NMR
confocal microscopy
genotyping
PCRs
PCR
gel filtration
saturation binding

Software Mentioned

Leica LAS X Life Science
DiameterJ
Matlab
ProtParam
CONSURF
Spectrum Identification Machine ( SIM - XL )
MSconvert
FeatureJ
GUSSI
MetaMorph

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