PMID: 6111338Dec 4, 1980Paper

The comparative ability of plasma and tissue transglutaminases to use collagen as a substrate

Biochimica Et Biophysica Acta
M M JeleńskaM Kopeć

Abstract

Heat denatured type I and type III calf skin collagen were found to be substrates for guinea pig liver transglutaminase (R-glutaminyl-peptide:amine gamma-glutamyl-yltransferase, EC 2.3.2.13) but not for active plasma factor XIII (factor XIIIa). Liver transglutaminase was shown to catalyse incorporation of 14C-putrescine into subunits of denatured collagen of both types, cross-linking of the latter into high molecular weight polymers and their co-cross-linking to fibrin and fibrinogen. Factor XIIIa is inactive in these respects. None of these reactions was catalysed by liver transglutaminase and plasma factor XIIIa when nondenatured collagens both soluble or in the forms of reconstituted fibrils served as substrates. Some cross-linking of cleavage products of collagen type I (obtained by treatment with collagenase from human neutrophiles) was induced by liver transglutaminase and factor XIIIa. The results indicate that although appropriate glutamine and lysine residues for a epsilon-(gamma-glutamine) lysine cross-linked formation are present in collagen, the native conformation of collagen prevents the action of liver transglutaminase and factor XIIIa.

References

Nov 1, 1975·Hoppe-Seyler's Zeitschrift für physiologische Chemie·T Fujii, K Kühn
Sep 9, 1977·Biochemical and Biophysical Research Communications·P J BirckbichlerM K Patterson
Nov 1, 1977·European Journal of Biochemistry·V Iwanij
Sep 1, 1979·The Journal of Clinical Investigation·D F Mosher, P E Schad
Jan 1, 1977·Advances in Protein Chemistry·J E Folk, J S Finlayson
Nov 15, 1975·Experientia·A SoriaC Boulard
Dec 1, 1991·The Journal of Clinical Investigation·T WakitaT Morishima
Dec 8, 1972·Annals of the New York Academy of Sciences·S I Chung
Aug 1, 1955·The Biochemical Journal·R A KEKWICKB R RECORD
Sep 1, 1960·The Biochemical Journal·J H FESSLER

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Citations

Jan 1, 1988·Neurosurgical Review·T Herter
Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T HerterD Windmann
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·S LustigmanA M Prince
May 10, 2008·Journal of Biomedical Materials Research. Part a·Dimitrios I ZeugolisGeoffrey Attenburrow
Apr 9, 2009·Journal of Biomedical Materials Research. Part a·D I ZeugolisM Raghunath
Jun 9, 2016·Amino Acids·Thung-S LaiCharles S Greenberg
May 1, 1982·Applied Biochemistry and Biotechnology·M Misawa, T Suzuki

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