The comparative cost-effectiveness of colorectal cancer screening using faecal immunochemical test vs. colonoscopy

Scientific Reports
Martin C S WongJoseph J Y Sung

Abstract

Faecal immunochemical tests (FITs) and colonoscopy are two common screening tools for colorectal cancer(CRC). Most cost-effectiveness studies focused on survival as the outcome, and were based on modeling techniques instead of real world observational data. This study evaluated the cost-effectiveness of these two tests to detect colorectal neoplastic lesions based on data from a 5-year community screening service. The incremental cost-effectiveness ratio (ICER) was assessed based on the detection rates of neoplastic lesions, and costs including screening compliance, polypectomy, colonoscopy complications, and staging of CRC detected. A total of 5,863 patients received yearly FIT and 4,869 received colonoscopy. Compared with FIT, colonoscopy detected notably more adenomas (23.6% vs. 1.6%) and advanced lesions or cancer (4.2% vs. 1.2%). Using FIT as control, the ICER of screening colonoscopy in detecting adenoma, advanced adenoma, CRC and a composite endpoint of either advanced adenoma or stage I CRC was US$3,489, US$27,962, US$922,762 and US$23,981 respectively. The respective ICER was US$3,597, US$439,513, -US$2,765,876 and US$32,297 among lower-risk subjects; whilst the corresponding figure was US$3,153, US$14,852, US$184,162 ...Continue Reading

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Feb 10, 2018·Intestinal research·Jin Young YoonUNKNOWN Quality Improvement Committee of Korean Society of Gastrointestinal Endoscopy (KSGE)
Mar 25, 2017·Journal of the American Society of Nephrology : JASN·Christopher A CarlosUNKNOWN Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team
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May 28, 2021·Psycho-oncology·Belinda C GoodwinJoanne Aitken

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