PMID: 602882Dec 1, 1977Paper

The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs

Agents and Actions
K D Rainsford

Abstract

A new gastric assay was employed to screen for the ulcerogenic activity of non-steroid anti-inflammatory (NSAI) analgesic drugs. The technique involves exposing rats to brief periods of cold stress, which is not itself sufficient to cause mucosal damage, but does specifically sensitize the stomach to irritant or ulcerogenic actions of NSAI drugs. The assessment of gastric ulcerogenicity of some well-known anti-inflammatory/analgesic drugs using this new assay was shown to agree well with clinical reports of the occurrence of gastric ulceration and haemorrhage. This assay was employed to screen for the ulcrogenicity of some new anti-inflammatory drugs and for potential drug interactions resulting from administration of certain frequently used combinations of these drugs.

References

Oct 1, 1975·Agents and Actions·K D Rainsford
Jan 1, 1976·Drugs·A R Cooke
Jan 1, 1973·Clinical Pharmacology and Therapeutics·J R Leonards, G Levy
Feb 1, 1974·Southern Medical Journal·J C Bowen, W H Fleming
May 1, 1974·The American Journal of Digestive Diseases·D C SunD W Englund
Mar 25, 1967·The Medical Journal of Australia·A Skyring, K Bhanthumnavin
Aug 1, 1974·British Journal of Clinical Pharmacology·P M BrooksW C Dick

❮ Previous
Next ❯

Citations

Dec 1, 1983·Veterinary Research Communications·Y Ruckebusch, P L Toutain
Sep 1, 1979·The Journal of Pharmacy and Pharmacology·J R Walker, M J Smith
Jan 10, 2012·Chemical & Pharmaceutical Bulletin·Fatma Abd El-Fattah RagabYassin Mohammed Nissan
Jan 22, 2010·Cellular and Molecular Life Sciences : CMLS·Svenja D SteinbrinkThorsten J Maier
Sep 1, 1990·Journal of Veterinary Internal Medicine·L F KarcherJ M King
Jun 1, 1990·Archiv der Pharmazie·M KajitaniH Fujimura
Jun 15, 1983·Toxicology and Applied Pharmacology·A A Van KolfschotenJ Van Noordwijk
Jan 1, 1980·Pharmacological Research Communications·K D Rainsford, M W Whitehouse
Oct 1, 1983·Biopharmaceutics & Drug Disposition·M R DobrinskaH E Paulus
Aug 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C G CurtisC Rhodes
Feb 16, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Halis SüleymanKonca Altinkaynak
Jan 1, 1988·Toxicologic Pathology·G A ElliottR H Denlinger
Jan 1, 1988·Toxicologic Pathology·K D Rainsford
Mar 1, 1983·Pharmacotherapy·Richard O Davies
Jan 1, 1981·The Journal of International Medical Research·R Weissenbach
Jun 23, 2000·The Journal of Pharmacy and Pharmacology·M J Deninger, R D Schoenwald
Nov 1, 1988·The Journal of International Medical Research·L CadedduS Sellari Franceschini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.