PMID: 7336757Nov 1, 1981Paper

The comparative metabolism of 2-bromoethanol and ethylene oxide in the rat

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
A R Jones, G Wells

Abstract

1. The metabolism of 2-bromo[U-14C]ethanol an [U-14C]ethylene oxide has been studied in the rat. 2. As both compounds give rise to similar amounts of two urinary metabolites, identified as S-(2-hydroxyethyl)cysteine and N-acetyl-S-(2-hydroxyethyl)cysteine, it is proposed that 2-bromoethanol is converted into ethylene oxide in vivo. 3. A minor metabolite of 2-bromoethanol has been identified as N-acetyl-S-(carboxymethyl)cysteine. 4. The metabolism of bromoacetaldehyde and bromoacetic acid has been investigated; N-acetyl-S-(carboxymethyl)cysteine had been shown to be a common urinary metabolite. 5. An oxidative metabolic pathway is proposed for 2-bromoethanol, via bromoacetaldehyde and bromoacetic acid, to N-acetyl-S-(carboxymethyl)cysteine.

References

May 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R H Waring
Oct 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A R Jones, G Fakhouri
Jul 1, 1977·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K M Rogers, E A Barnsley
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Jan 1, 1971·Acta Pharmacologica Et Toxicologica·S Yllner
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Nov 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A R Jones, J Gibson

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Citations

Apr 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·B R Pettit
Dec 1, 1994·Environmental Health Perspectives·D KrewskiM E Andersen
Jan 1, 1992·Critical Reviews in Toxicology·R T van WelieN J van Sittert
Jan 1, 1986·Drug and Chemical Toxicology·J A McKelvey, M A Zemaitis
Jan 1, 1989·Journal of Biochemical Toxicology·B S Kaphalia, G A Ansari
Dec 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M S DobbieA R Jones
Mar 14, 1998·Toxicology and Applied Pharmacology·C D BrownT R Fennell
Jul 5, 2001·Toxicology and Applied Pharmacology·T R Fennell, C D Brown
May 1, 1992·Toxicology and Industrial Health·K KrishnanM E Andersen
Jan 16, 1999·Journal of Biochemical and Molecular Toxicology·L E ThielemannL A Videla
Dec 1, 1991·Regulatory Toxicology and Pharmacology : RTP·R NilssonE V Sargent

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