The comparative toxicity and therapeutic efficacy of adriamycin and the adriamycin-DNA complex in the chemotherapy of C3H mice with transplanted mammary adenocarcinoma

Cancer Letters
I Brown, H W Ward


Tissue analyses and tumour regression studies using the oncolytic antibiotic, adriamycin (14-hydroxydaunomycin), and its DNA complex at adriamycin dosages of 5 mg/kg and 10 mg/kg were made on C3H mice with transplanted mammary adenocarcinoma. Chemical analysis indicated a significantly lower (P < 0.05) uptake of adriamycin into cardiac tissue for the adriamycin-DNA complex. Tumour regression was comparable for both the complex and free adriamycin. Results suggest an advantageous role for the adriamycin DNA complex in the chemotherapy of metastatic breast carcinoma.


Jan 1, 1987·Medicinal Research Reviews·D R Friend, S Pangburn


Oct 1, 1973·Cancer·L M BujaE S Henderson
Jul 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Atassi, H J Tagnon
Jun 1, 1973·Biochemical Medicine·H S Schwartz

Related Concepts

Neoplasm Transplantation
Tumor Lysis Syndrome
Mice, Inbred C3H
Injections, Intraperitoneal
Carcinoma, Cribriform

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