Jan 1, 1976

The comparison of aminotransferase activities in normal and Guerin epithelioma bearing rats

Neoplasma
L JaroszewiczW Rzeczycki

Abstract

The activities of 13 aminotransferawes in Guerin epithelioma and in the liver of normal and tumor bearing rats were investigated. Alanine and aspartate aminotransferases show the highest activity in all investigated tissues. In the liver of normal rats high arginine, tyrosine and phenylalanine aminotransferase activities were found. In tumor tissue high level of branched chain amino acid (leucine, valine and isoleucine) aminotransferases were observed. Increase in aminotransferase activities in the liver of tumor bearing rats was found. In order to elucidate the mechanism of this increase an inductive effect of hydrocortisone and protein free extract of tumor tissue on liver aminotransferases has been investigated. The tumor extract did not exert an inductive action. An inductive effect of hydrocortisone was not identical with the change in aminotransferase activities observed in the liver of tumor bearing rats.

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Mentioned in this Paper

Phenylalanine aminotransferase
Exertion
Valine
Tumor Tissue Sample
Tyrosine Aminotransferase
Aminotransferase Activity
Aspartate Transaminase
Isoleucine Measurement
Transaminases
Arginine

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