The comparison of the effectiveness between different doses of local methylprednisolone injection versus triamcinolone in Carpal Tunnel Syndrome: a double-blind clinical trial

Journal of Pain Research
Afshin KarimzadehHadi Shirzad

Abstract

Local corticosteroid injection is one of the most prevalent methods in treating carpal tunnel syndrome (CTS). However, the most efficient substance and its appropriate dosage remain controversial. In the present double-blind randomized controlled trial, the efficacy and safety of local injection of two corticosteroids (triamcinolone and methylprednisolone) were compared at two different dosages, 20 and 40 mg. We consecutively included 80 patients with mild or moderate CTS and randomly assigned them to four groups: 20 or 40 mg triamcinolone (T20 or T40) and 20 or 40 mg methylprednisolone (M20 or M40) groups; each patient received a single injection of steroid using conventional approach. The four groups were relatively comparable and did not show any significant difference initially in their baseline measurements including pain intensity measured using VAS, pain-free grip strength (PFGS), nerve conduction study (NCS), and two parts of Boston Carpal Tunnel Syndrome Questionnaire: symptom severity scale (SSS) and functional status scale (FSS); the latter was our primary outcome measure. Three months after injection, they were reassessed to evaluate the clinical and electrodiagnostic changes. Almost all NCS parameters, VAS, and PFG...Continue Reading

Citations

Apr 1, 2020·JBJS Reviews·Jana DenglerAmy M Moore
Mar 7, 2021·International Journal of Environmental Research and Public Health·Mar Hernández-SecorúnMaría Orosia Lucha-López
Jun 10, 2021·Hand : Official Journal of the American Association for Hand Surgery·Omolola FakunleCharles A Daly

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