The Comparison of the Efficacy of Baloxavir and Neuraminidase Inhibitors for Patients with Influenza A in Clinical Practice

Internal Medicine
Naoko YoshiiTomoya Kawaguchi

Abstract

Objective Baloxavir marboxil is a novel anti-influenza drug reported to have an early antiviral effect, although it also causes the appearance of variant viruses with a reduced susceptibility to baloxavir. In Japan, four neuraminidase inhibitors (NAIs) have been commonly used to treat patients with influenza. In clinical practice, the differences in the effects of baloxavir and NAIs have not been sufficiently examined. Our objective was to clarify the clinical differences in efficacy between baloxavir and NAIs. Methods A multicenter, observational study was conducted using postcard questionnaires during the 2018-19 influenza season. Patients who were prescribed anti-influenza drugs were provided postcard questionnaires asking about their background characteristics and their body temperatures. The factors associated with the early alleviation of the fever were analyzed, and the duration of the fever was compared between the baloxavir group and the NAI group. Results A total of 295 patients with influenza A, ranging in age from 0-91 years old, were enrolled in this study. A multivariate analysis showed that treatment with baloxavir and a duration from the onset to the start of treatment ≥2.5 days were factors contributing to the ...Continue Reading

References

Nov 17, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naoki KawaiSeizaburo Kashiwagi
Oct 13, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Akira WatanabeUNKNOWN MARVEL Study Group
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jaime E HernandezUNKNOWN eIND Peramivir Investigators
Jul 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Janice K LouieTimothy M Uyeki
Dec 31, 2016·Current Treatment Options in Infectious Diseases·Hassan Zaraket, Reiko Saito
Mar 18, 2017·Lancet·Catharine Paules, Kanta Subbarao
Jul 16, 2017·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hideyuki IkematsuSeizaburo Kashiwagi
Sep 6, 2018·The New England Journal of Medicine·Frederick G HaydenUNKNOWN Baloxavir Marboxil Investigators Group
Dec 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy M UyekiAndrew T Pavia
Sep 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nobuo HirotsuAkira Watanabe

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