The Compelling Demand for an Effective PrPC -Directed Therapy against Prion Diseases

ACS Medicinal Chemistry Letters
Andrea AstolfiMaria Letizia Barreca

Abstract

Decades of research efforts have conclusively provided overwhelming evidence that the cellular prion protein (PrPC) plays a central role in prion diseases, a set of fatal and incurable neurodegenerative disorders for which no therapy is yet available. In this Viewpoint, we provide an overview of the drug discovery strategies in the field, highlighting the current therapeutic hypotheses targeting, whether directly or indirectly, PrPC as well as the antiprion agents closest to clinical application.

References

Mar 16, 2016·Scientific Reports·Tania MassignanEmiliano Biasini
Sep 26, 2017·Nature Neuroscience·Diana G FerreiraTiago F Outeiro
Mar 10, 2018·Pathogens·Maria Letizia BarrecaEmiliano Biasini
Sep 21, 2018·PLoS Pathogens·Cheng FangDavid A Harris
Oct 26, 2018·Annual Review of Pathology·Christina J SigurdsonMarkus Glatzel
Jan 27, 2019·Current Opinion in Pharmacology·Robert Cc Mercer, David A Harris
Jul 31, 2019·JCI Insight·Gregory J RaymondSonia M Vallabh
Sep 29, 2019·Current Medicinal Chemistry·Carlo MustazzaCarla Raggi
Mar 22, 2020·Lancet Neurology·Sonia M VallabhEric S Lander
Apr 7, 2020·Nature Medicine·Archna Bajaj, Daniel J Rader
May 18, 2020·Trends in Pharmacological Sciences·Yu DingBoxun Lu
Jul 8, 2020·Expert Opinion on Therapeutic Targets·Arianna Colini BaldeschiGiuseppe Legname
Jul 30, 2020·The Journal of Biological Chemistry·Andrew G ReidenbachEric Vallabh Minikel

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Citations

Feb 7, 2021·Cell Stress & Chaperones·Jennifer AbramsJason E Gestwicki
Jun 11, 2021·Journal of Computer-aided Molecular Design·Mariangela AgamennoneRoberto Paciotti
Jul 6, 2021·RSC Medicinal Chemistry·Silke Miller, Maria-Jesus Blanco

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Methods Mentioned

BETA
antisense oligonucleotides
GTPase

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