Abstract
The complement system is an essential component of the innate immune system that aids the recognition and destruction of pathogens. Despite the potent cytolytic activity of this system, some pathogens have turned interactions with complement to their advantage. Transmissible spongiform encephalopathies (TSEs), or prion diseases, also seem to use the complement system to facilitate target cell infection in lymphoid tissues. TSEs are associated with the accumulation of disease-specific prion protein in the brain, which is accompanied by progressive neurodegeneration. Unregulated activation of complement can cause host tissue damage, as observed in some neurodegenerative disorders, and active complement components have been detected in the brains of hosts with TSEs. Whether complement inhibitors will be useful to treat TSEs remains to be determined.
References
Dec 1, 1992·The Journal of Pathology·P A McBrideM E Bruce
Dec 24, 1982·Science·D C BoltonS B Prusiner
Jan 27, 1998·The Journal of Biological Chemistry·P R TaylorM Botto
May 20, 1998·Nature Genetics·M BottoM J Walport
Dec 10, 1998·Nature Medicine·M A KleinA Aguzzi
Jan 29, 1999·Lancet·A F HillJ Collinge
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·A J RaeberC Weissmann
Jul 16, 1999·Journal of Comparative Pathology·S McHattieN Edington
May 20, 2000·Science·F MontrasioC Weissmann
Jul 25, 2000·Immunopharmacology·P GasqueB P Morgan
Oct 12, 2000·Journal of Virology·C RiemerM Baier
Jun 21, 2001·Immunological Reviews·H StoiberM P Dierich
Sep 20, 2001·The Journal of General Virology·N A Mabbott, M E Bruce
Dec 26, 2001·The Journal of General Virology·Fang-Ping HuangG Gordon MacPherson
Jan 25, 2002·The Journal of General Virology·Ragna HeggebøMartin Jeffrey
Mar 22, 2002·Acta Neuropathologica·Kensuke SasakiToru Iwaki
May 30, 2002·Nature Reviews. Immunology·Teizo Fujita
Jun 27, 2002·Transfusion·G Robin BarclayMarc L Turner
Mar 1, 2003·Journal of Virology·Hanna LewickiMichael B A Oldstone
May 28, 2003·Journal of Virology·Neil A MabbottMoira E Bruce
Jan 31, 2004·Neurobiology of Disease·Gabor G KovacsMarin Guentchev
Dec 1, 2004·Immunobiology·Neil A Mabbott, Moira E Bruce
Citations
Feb 8, 2006·Nature Reviews. Microbiology·Neil A Mabbott, G Gordon MacPherson
Jul 14, 2010·Médecine sciences : M/S·Véronique Bachy, Pierre Aucouturier
Jan 25, 2013·Viruses·Barry M Bradford, Neil A Mabbott
Jun 14, 2008·Expert Opinion on Biological Therapy·Sabine GilchHermann M Schätzl
Feb 23, 2013·Veterinary Immunology and Immunopathology·Katrin KomolkaManfred Schwerin
Jun 9, 2012·Scientific Reports·Brady MichelMark D Zabel
Sep 20, 2005·Veterinary Immunology and Immunopathology·Anton GossnerJohn Hopkins
Sep 24, 2015·Molecular Neurobiology·Li-Na ChenXiao-Ping Dong
Sep 14, 2018·BMC Veterinary Research·Siv MelingMartha J Ulvund
Nov 14, 2019·Medical Microbiology and Immunology·Cao ChenXiao-Ping Dong
Dec 20, 2016·Proteomics. Clinical Applications·Qi ShiXiao-Ping Dong