The complement system in prion diseases

Current Opinion in Immunology
N A Mabbott

Abstract

The complement system is an essential component of the innate immune system that aids the recognition and destruction of pathogens. Despite the potent cytolytic activity of this system, some pathogens have turned interactions with complement to their advantage. Transmissible spongiform encephalopathies (TSEs), or prion diseases, also seem to use the complement system to facilitate target cell infection in lymphoid tissues. TSEs are associated with the accumulation of disease-specific prion protein in the brain, which is accompanied by progressive neurodegeneration. Unregulated activation of complement can cause host tissue damage, as observed in some neurodegenerative disorders, and active complement components have been detected in the brains of hosts with TSEs. Whether complement inhibitors will be useful to treat TSEs remains to be determined.

References

Dec 24, 1982·Science·D C BoltonS B Prusiner
Dec 10, 1998·Nature Medicine·M A KleinA Aguzzi
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·A J RaeberC Weissmann
Jul 16, 1999·Journal of Comparative Pathology·S McHattieN Edington
Oct 12, 2000·Journal of Virology·C RiemerM Baier
Jun 21, 2001·Immunological Reviews·H StoiberM P Dierich
Sep 20, 2001·The Journal of General Virology·N A Mabbott, M E Bruce
Dec 26, 2001·The Journal of General Virology·Fang-Ping HuangG Gordon MacPherson
May 30, 2002·Nature Reviews. Immunology·Teizo Fujita
Mar 1, 2003·Journal of Virology·Hanna LewickiMichael B A Oldstone
Jan 31, 2004·Neurobiology of Disease·Gabor G KovacsMarin Guentchev
Dec 1, 2004·Immunobiology·Neil A Mabbott, Moira E Bruce

❮ Previous
Next ❯

Citations

Feb 8, 2006·Nature Reviews. Microbiology·Neil A Mabbott, G Gordon MacPherson
Jul 14, 2010·Médecine sciences : M/S·Véronique Bachy, Pierre Aucouturier
Jan 25, 2013·Viruses·Barry M Bradford, Neil A Mabbott
Jun 14, 2008·Expert Opinion on Biological Therapy·Sabine GilchHermann M Schätzl
Jun 9, 2012·Scientific Reports·Brady MichelMark D Zabel
Sep 20, 2005·Veterinary Immunology and Immunopathology·Anton GossnerJohn Hopkins
Nov 14, 2019·Medical Microbiology and Immunology·Cao ChenXiao-Ping Dong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.