The Complement System Is Critical in Maintaining Retinal Integrity during Aging

Frontiers in Aging Neuroscience
Ryo MukaiKip M Connor

Abstract

The complement system is a key component of innate immunity comprised of soluble components that form a proteolytic cascade leading to the generation of effector molecules involved in cellular clearance. This system is highly activated not only under general inflammatory conditions such as infections, collagen diseases, nephritis, and liver diseases, but also in focal ocular diseases. However, little is known about the role of the complement system in retinal homeostasis during aging. Using young (6-week-old) and adult (6-month-old) mice in wild type (C57BL/6) and complement knockout strains (C1q-/-,Mbl a/c-/-,Fb-/-,C3-/-, andC5-/-), we compared amplitudes of electroretinograms (ERG) and thicknesses of retinal layers in spectral domain optical coherence tomography between young and adult mice. The ERG amplitudes in adult mice were significantly decreased (p< 0.001,p< 0.0001) compared to that of young mice in all complement knockout strains, and there were significant decreases in the inner nuclear layer (INL) thickness in adult mice compared to young mice in all complement knockout strains (p< 0.0001). There were no significant differences in ERG amplitude or thickness of the INL between young and adult control mice. These data...Continue Reading

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Sep 24, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Katrine Laura RasmussenSune Fallgaard Nielsen
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Nov 28, 2021·Journal of Clinical Medicine·Paola TriggianeseMassimo Cesareo
Dec 9, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Heather G MackSamantha Fraser-Bell

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Methods Mentioned

BETA
light microscopy
electron microscopy

Software Mentioned

Bioptigen

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