The complement system plays a critical role in the development of experimental autoimmune anterior uveitis

Investigative Ophthalmology & Visual Science
Purushottam JhaNalini S Bora

Abstract

The role of complement in ocular autoimmunity was explored in a experimental autoimmune anterior uveitis (EAAU) animal model. EAAU was induced in Lewis rats by immunization with bovine melanin-associated antigen. Complement activation in the eye was monitored by Western blot for iC3b. The importance of complement to the development of EAAU was studied by comparing the course of intraocular inflammation in normal Lewis rats (complement-sufficient) with cobra venom factor-treated rats (complement-depleted). Eyes were harvested from both complement-sufficient and complement-depleted rats for mRNA and protein analysis for IFN-gamma, IL-10, and interferon-inducible protein (IP)-10. Intracellular adhesion molecule (ICAM)-1 and leukocyte-endothelial cell adhesion molecule (LECAM)-1 were detected by immunofluorescent staining. OX-42 was used to investigate the importance of iC3b and CR3 interaction in EAAU. There was a correlation between ocular complement activation and disease progression in EAAU. The incidence, duration, and severity of disease were dramatically reduced after active immunization in complement-depleted rats. Complement depletion also completely suppressed adoptive transfer EAAU. The presence of complement was critica...Continue Reading

References

Aug 1, 1995·Clinical and Experimental Immunology·M J PalmenE P van Rees
Feb 1, 1993·Current Opinion in Immunology·S Tomlinson
Apr 3, 2001·Nature Medicine·M A KleinA Aguzzi
Nov 15, 2001·Annals of Neurology·J W PrineasB P Morgan
Jan 5, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aikaterini A PapagianniMenelaos Papadimitriou
Feb 14, 2002·Resuscitation·Timothy H Rainer
Feb 28, 2003·FEBS Letters·Anne-Christine JauneauMarc Fontaine
Apr 18, 2003·Clinical and Experimental Immunology·L Adorini
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tiphaine MonsinjonMarc C Fontaine
Feb 26, 2004·The American Journal of Pathology·Eric A AlbrechtPeter A Ward
Jun 29, 2004·Progress in Retinal and Eye Research·Graham R WallacePhilip I Murray
Sep 30, 2004·Nature Immunology·Michael C Carroll
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Puran S BoraNalini S Bora

❮ Previous
Next ❯

Citations

Sep 17, 2009·The Journal of Biological Chemistry·Purushottam JhaNalini S Bora
Jan 11, 2011·The Journal of Biological Chemistry·Balasubramanian ManickamNalini S Bora
Aug 24, 2013·The British Journal of Ophthalmology·Ming-ming YangChi Pui Pang
Sep 4, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ying TanMing-Hui Zhao
Feb 27, 2008·Seminars in Immunopathology·Nalini S BoraPuran S Bora
Mar 26, 2010·Immunobiology·Johanna K ZippliesCornelia A Deeg
Jun 30, 2009·Progress in Retinal and Eye Research·Heping XuJohn V Forrester
Oct 4, 2008·The American Journal of Pathology·Bharati MattaNalini S Bora
Aug 7, 2014·Journal of Ophthalmic Inflammation and Infection·Joanne Yw NgChi-Pui Pang
Dec 17, 2008·Veterinary Ophthalmology·Cornelia A Deeg
Sep 16, 2006·Immunological Reviews·Rachel R Caspi
Dec 17, 2009·Clinical and Experimental Immunology·D A CoplandL B Nicholson
Apr 2, 2013·Progress in Retinal and Eye Research·Katharina BellFranz H Grus
Oct 25, 2011·The American Journal of Pathology·Jinyan ZhangZhihai Peng
Sep 4, 2010·The American Journal of Pathology·Valeriy V LyzogubovPuran S Bora
Nov 21, 2007·Current Eye Research·Vanessa MontalvoIgal Gery
Sep 5, 2007·Molecular Immunology·Purushottam JhaNalini S Bora
Oct 6, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Joshua M Thurman, Brandon Renner
Apr 30, 2008·Archives of Environmental Contamination and Toxicology·Manoj AggarwalJ K Malik
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Purushottam JhaNalini S Bora
Sep 14, 2007·Current Eye Research·M KramerN Goldenberg-Cohen
Sep 28, 2017·Seminars in Immunopathology·Simon J Clark, Paul N Bishop
Jan 26, 2021·Frontiers in Immunology·Roxane L Degroote, Cornelia A Deeg
May 18, 2021·Frontiers in Immunology·Charles E EgwuaguEvaristus C Mbanefo
Oct 27, 2006·Current Opinion in Ophthalmology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.