PMID: 9177475May 2, 1997Paper

The complete amino acid sequence of human placental oxytocinase

Biochimica Et Biophysica Acta
P G LaustsenT Kristensen

Abstract

The complete amino acid sequence of human placental oxytocinase (placental leucine aminopeptidase) has been determined by cDNA cloning and sequencing. Oxytocinase is a type II integral membrane protein of 1025 amino acid residues, consisting of an acidic intracellular region of 110 amino acids followed by a hydrophobic transmembrane segment of 22 residues and 893 extracellular residues containing the characteristic Zn2+ coordination sequence element His-Glu-Xaa-Xaa-His-(18 residues)-Glu found in gluzincins. Two sets of cDNA clones with different 5'-ends were isolated and suggested to represent different spliced products of 3.6 kb (mature mRNA) and 12 kb, respectively. Oxytocinase mRNA is present in large amounts in placenta, heart and skeletal muscle and in small amounts in brain, kidney, liver and pancreas. A conserved sequence element, the GAMEN motif, which distinguishes the aminopeptidase family among gluzincins from other gluzincins, has been identified.

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Citations

May 17, 2005·Biochimica Et Biophysica Acta·Seiji NomuraShigehiko Mizutani
Jan 7, 2004·Biochemical and Biophysical Research Communications·Hiroshi FujiwaraShingo Fujii
Jan 31, 2004·Biochemical and Biophysical Research Communications·Norio ItoShigehiko Mizutani
Apr 12, 2000·European Journal of Biochemistry·T E RasmussenT Kristensen
Dec 20, 2000·European Journal of Biochemistry·P G LaustsenT Kristensen
Aug 22, 2002·The Journal of Clinical Investigation·Xinle CuiStewart J Levine
Nov 11, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Makoto KawaiYukichi Hara
Sep 29, 2007·Pharmacology & Therapeutics·Anthony L AlbistonSiew Yeen Chai
Aug 2, 2005·Biochimica Et Biophysica Acta·Masafumi Tsujimoto, Akira Hattori
Jan 11, 2013·International Journal of Hypertension·Hanna Andersson, Mathias Hallberg
Dec 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Honami KobayashiShigehiko Mizutani
Sep 13, 2006·Journal of Peptide Science : an Official Publication of the European Peptide Society·Andreas AxénMathias Hallberg
Sep 27, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C DingF Magkos
May 12, 2005·The Biochemical Journal·Hilde LaeremansPatrick M L Vanderheyden
Oct 20, 2020·Frontiers in Pharmacology·Dimitris GeorgiadisAntonia Papasava
Apr 5, 2008·Journal of Medicinal Chemistry·Aneta LukaszukDirk Tourwé

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