The complete genome of Enterovirus 71 China strain

Science in China. Series C, Life Sciences
Fan YangY Hou

Abstract

Five overlapping clones covering the full genome of Enterovirus 71 China strain SHZH98 were obtained and then the sequences were determined by the chain termination method. It showed that the full length of EV71 SHZH98 genome (not including Poly A tail) is 7408 bp. There are some diversities on the lengths and sequences of 5' UTR and 3' UTR between SHZH98 and the other EV71 strains. In P1 capsid region, which is closely associated with viral immunogenicity, EV71 strain SHZH98 shares the highest homology with Taiwan strains; but in P2 and P3 non-structural gene regions there are higher identities with Coxsakievirus A16 and EV71 strains MS, BrCr than with Taiwan strains. Phylogenetic tree constructed by structural gene region indicates that China strain SHZH98 has a closer relationship with Taiwan strains, however, in the non-coding region it has a closer relationship with Coxsakievirus A16, EV71 strains MS and BrCr. EV71 China strain was analyzed at the molecular level. The results will contribute to the basic study on enteroviruses and the EV71 prevention in China.

Citations

Mar 15, 2011·Journal of Molecular Biology·Sheng CuiQi Jin
Aug 7, 2013·Science China. Life Sciences·George Fu Gao, Ying Wu
May 26, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yoke-Fun ChanSazaly AbuBakar
Mar 4, 2014·Antiviral Research·Qingwei LiuZhong Huang
Aug 27, 2013·Journal of Molecular Biology·Zhixia MuSheng Cui

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