The Complete Genome Sequence of Clostridium aceticum: a Missing Link between Rnf- and Cytochrome-Containing Autotrophic Acetogens

MBio
Anja PoehleinP Dürre

Abstract

Clostridium aceticum was the first isolated autotrophic acetogen, converting CO2 plus H2 or syngas to acetate. Its genome has now been completely sequenced and consists of a 4.2-Mbp chromosome and a small circular plasmid of 5.7 kbp. Sequence analysis revealed major differences from other autotrophic acetogens. C. aceticum contains an Rnf complex for energy conservation (via pumping protons or sodium ions). Such systems have also been found in C. ljungdahlii and Acetobacterium woodii. However, C. aceticum also contains a cytochrome, as does Moorella thermoacetica, which has been proposed to be involved in the generation of a proton gradient. Thus, C. aceticum seems to represent a link between Rnf- and cytochrome-containing autotrophic acetogens. In C. aceticum, however, the cytochrome is probably not involved in an electron transport chain that leads to proton translocation, as no genes for quinone biosynthesis are present in the genome. Autotrophic acetogenic bacteria are receiving more and more industrial focus, as CO2 plus H2 as well as syngas are interesting new substrates for biotechnological processes. They are both cheap and abundant, and their use, if it results in sustainable products, also leads to reduction of greenh...Continue Reading

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Citations

Feb 24, 2016·FEMS Microbiology Letters·Peter Dürre
Dec 5, 2015·Genome Announcements·Frank R BengelsdorfPeter Dürre
May 28, 2016·Genome Announcements·Genis Andrés Castillo Villamizar, Anja Poehlein
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Jul 28, 2016·Frontiers in Microbiology·Frank R BengelsdorfPeter Dürre
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Oct 30, 2016·Microbial Biotechnology·Peter Dürre
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Dec 23, 2016·Genome Announcements·Anja PoehleinPeter Dürre
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Mar 25, 2017·Genome Announcements·Genis Andrés Castillo VillamizarAnja Poehlein
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May 5, 2018·Genome Announcements·Anja PoehleinRolf Daniel
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Jul 15, 2020·Biochimica Et Biophysica Acta. Bioenergetics·Martin KuhnsVolker Müller

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Datasets Mentioned

BETA
CP009687
CP009688

Methods Mentioned

BETA
protein assay

Software Mentioned

TBLASTx
tRNAscan
Prodigal
MEGA6
ER genomes - expert review
BLASTp
IMG
Roche Newbler Assembly
Mira
Easyfig

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