The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403

Genome Research
A BolotinA Sorokin

Abstract

Lactococcus lactis is a nonpathogenic AT-rich gram-positive bacterium closely related to the genus Streptococcus and is the most commonly used cheese starter. It is also the best-characterized lactic acid bacterium. We sequenced the genome of the laboratory strain IL1403, using a novel two-step strategy that comprises diagnostic sequencing of the entire genome and a shotgun polishing step. The genome contains 2,365,589 base pairs and encodes 2310 proteins, including 293 protein-coding genes belonging to six prophages and 43 insertion sequence (IS) elements. Nonrandom distribution of IS elements indicates that the chromosome of the sequenced strain may be a product of recent recombination between two closely related genomes. A complete set of late competence genes is present, indicating the ability of L. lactis to undergo DNA transformation. Genomic sequence revealed new possibilities for fermentation pathways and for aerobic respiration. It also indicated a horizontal transfer of genetic information from Lactococcus to gram-negative enteric bacteria of Salmonella-Escherichia group.

References

Nov 1, 1992·Journal of Bacteriology·P Le BourgeoisP Ritzenthaler
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jul 1, 1993·Journal of Bacteriology·J J GodonP Renault
Sep 1, 1993·FEMS Microbiology Reviews·B Poolman
Oct 1, 1996·Antonie van Leeuwenhoek·M Cocaign-BousquetN D Lindley
Jul 1, 1997·Applied and Environmental Microbiology·G BuistJ Kok
Aug 1, 1997·Electrophoresis·C M Fraser, R D Fleischmann
Oct 24, 1997·Science·R L TatusovD J Lipman
Jan 20, 1998·Trends in Genetics : TIG·M DsouzaR Overbeek
Aug 8, 1998·The Journal of Biological Chemistry·A BolhuisJ M van Dijl
Mar 27, 1999·Journal of Molecular Biology·Y QuentinF Denizot
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·H OchmanN A Moran
Dec 1, 1993·Applied and Environmental Microbiology·P R Jensen, K Hammer

❮ Previous
Next ❯

Citations

May 10, 2001·Journal of Bacteriology·V MonederoJ Deutscher
Jun 8, 2001·Journal of Bacteriology·S EvenM Cocaign-Bousquet
Aug 30, 2001·Applied and Environmental Microbiology·Y Le LoirP Langella
Mar 27, 2002·Journal of Bacteriology·Arvind K Bansal, Terrance E Meyer
Apr 27, 2002·Applied and Environmental Microbiology·Nathalie CampoPascal Le Bourgeois
Jun 1, 2002·Applied and Environmental Microbiology·Martin B PedersenDan Nilsson
Jun 1, 2002·Applied and Environmental Microbiology·A MiyoshiP Langella
Jun 12, 2002·Journal of Bacteriology·Ola WeenLeiv Sigve Håvarstein
Jul 31, 2002·Applied and Environmental Microbiology·Marie-Christine Champomier-VergèsMonique Zagorec
Aug 30, 2002·Applied and Environmental Microbiology·Hélène DeveauSylvain Moineau
Oct 5, 2002·Nucleic Acids Research·Jan MrázekSamuel Karlin
Oct 11, 2002·Journal of Bacteriology·Lynn Hancock, Marta Perego
Oct 31, 2002·Applied and Environmental Microbiology·Martin B PedersenDan Nilsson
Oct 31, 2002·Applied and Environmental Microbiology·Jan SchirawskiDouwe Van Sinderen
Oct 31, 2002·Applied and Environmental Microbiology·Peter A BronPascal Hols
Nov 26, 2002·Journal of Bacteriology·Oleg V KurnasovAndrei L Osterman
Dec 18, 2002·Journal of Bacteriology·Thorsten MascherRegine Hakenbeck
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michiel KleerebezemRoland J Siezen
Mar 7, 2003·Applied and Environmental Microbiology·Marina Sánchez-HidalgoManuel Martínez-Bueno
May 6, 2003·Journal of Bacteriology·Peter van BerkumBertrand D Eardly
Jun 6, 2003·Applied and Environmental Microbiology·Wilbert SybesmaJeroen Hugenholtz
Jun 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christian SieboldUlrich Baumann
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dragana AjdićJoseph J Ferretti
Dec 14, 2001·Journal of Bacteriology·María FernándezRichard van Kranenburg
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tohru ShimizuHideo Hayashi
Jul 4, 2003·Applied and Environmental Microbiology·Isabelle BoucherSylvain Moineau
Sep 6, 2003·Applied and Environmental Microbiology·Jasna RakonjacPaul W O'Toole
Oct 9, 2003·Applied and Environmental Microbiology·Yin LiDouwe Molenaar
Oct 9, 2003·Applied and Environmental Microbiology·Mark S TurnerPhilip M Giffard
Jan 9, 2004·Applied and Environmental Microbiology·Balasubramanian Ganesan, Bart C Weimer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Bacterial Respiration (ASM)

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.