The complete genome sequence of the pathogenic intestinal spirochete Brachyspira pilosicoli and comparison with other Brachyspira genomes.

PloS One
Phatthanaphong WanchanthuekDavid J Hampson

Abstract

The anaerobic spirochete Brachyspira pilosicoli colonizes the large intestine of various species of birds and mammals, including humans. It causes "intestinal spirochetosis", a condition characterized by mild colitis, diarrhea and reduced growth. This study aimed to sequence and analyse the bacterial genome to investigate the genetic basis of its specialized ecology and virulence. The genome of B. pilosicoli 95/1000 was sequenced, assembled and compared with that of the pathogenic Brachyspira hyodysenteriae and a near-complete sequence of Brachyspira murdochii. The B. pilosicoli genome was circular, composed of 2,586,443 bp with a 27.9 mol% G+C content, and encoded 2,338 genes. The three Brachyspira species shared 1,087 genes and showed evidence of extensive genome rearrangements. Despite minor differences in predicted protein functional groups, the species had many similar features including core metabolic pathways. Genes distinguishing B. pilosicoli from B. hyodysenteriae included those for a previously undescribed bacteriophage that may be useful for genetic manipulation, for a glycine reductase complex allowing use of glycine whilst protecting from oxidative stress, and for aconitase and related enzymes in the incomplete TC...Continue Reading

References

Jun 1, 1992·Journal of Bacteriology·J J SchwartzI Schwartz
Jan 1, 1992·Microbiology and Immunology·M FukunagaM Seki
Mar 29, 1991·Biochemical and Biophysical Research Communications·B L SlomianyA Slomiany
Oct 1, 1990·Experimental Cell Research·G KonatE L Hogan
Jan 1, 1990·Microbiology and Immunology·M FukunagaY Yanagihara
Dec 1, 1988·Infection and Immunity·M R Halter, L A Joens
Oct 1, 1986·Journal of Clinical Microbiology·R A KunkleJ M Kinyon
Sep 7, 1974·The Veterinary Record·J M Kinyon, D L Harris
Oct 1, 1971·Biochemical and Biophysical Research Communications·R E Palmer, R L Anderson
May 1, 1995·Trends in Microbiology·C Whitfield
Jan 1, 1994·Antonie van Leeuwenhoek·J R Andreesen
Feb 1, 1994·Journal of Bacteriology·R L Zuerner, T B Stanton
May 1, 1993·Veterinary Microbiology·L A JoensM Halter
Jan 1, 1993·Journal of Clinical Microbiology·J I LeeD J Hampson
Jul 1, 1995·Research in Veterinary Science·C Fellström, A Gunnarsson
Oct 1, 1995·Veterinary Microbiology·A A ter Huurne, W Gaastra
Jan 1, 1996·International Journal of Systematic Bacteriology·D J TrottD J Hampson
Dec 1, 1996·Australian Veterinary Journal·J I Lee, D J Hampson
Jul 15, 1997·FEMS Microbiology Letters·C A Lichtensteiger, E R Vimr
Sep 23, 1997·FEMS Microbiology Letters·N Muniappa, G E Duhamel
Oct 23, 1997·International Journal of Systematic Bacteriology·T B StantonI Saint Girons
Feb 12, 1998·Journal of Clinical Microbiology·N L Trivett-MooreD J Hampson
Feb 24, 1999·Australian Veterinary Journal·D J HampsonS L Oxberry

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Citations

Dec 18, 2013·The Veterinary Record·M MahuF Boyen
Mar 8, 2013·Genome Announcements·Changyou LinGérald E Duhamel
Oct 6, 2012·Journal of Proteomics·Adriana CalderaroCarlo Chezzi
Sep 3, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Michael KisielaEdmund Maser
Apr 19, 2011·Veterinary Microbiology·A BackhansC Fellström
May 13, 2015·FEMS Microbiology Ecology·K Vinod KumarP Vijayachari
Dec 21, 2013·Veterinary Microbiology·Luke J MappleyMartin J Woodward
Sep 15, 2012·Gut Microbes·Gayatri Vedantam, V K Viswanathan
Aug 7, 2016·Frontiers in Microbiology·Vanessa CasasJoaquin Abian
Dec 1, 2017·Clinical Microbiology Reviews·David J Hampson
Dec 25, 2012·Natural Product Reports·Anne-Catrin LetzelChristian Hertweck
May 20, 2017·Frontiers in Microbiology·Vanessa CasasJoaquin Abian
Oct 27, 2017·Pathogens and Disease·Jason Byron D S PerezJanet E Hill
Nov 12, 2020·Microbial Genomics·Anish PandeyMyron Christodoulides
Dec 29, 2020·Gut·Robin C Spiller, Jonna Jalanka

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Datasets Mentioned

BETA
CP002025
48097
ABTG00000000

Methods Mentioned

BETA
PCR
deamination
acylation

Software Mentioned

Freckle
TMHMM
Newbler Assembler
Dotter tool
PSORT
SignalP
Blast
Artemis Comparison Tool

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