PMID: 2510401Nov 1, 1989Paper

The completed sequence of lymphocytic choriomeningitis virus reveals a unique RNA structure and a gene for a zinc finger protein

Virology
M Salvato, E Shimomaye

Abstract

The arenavirus, lymphocytic choriomeningitis virus (LCMV) has a single-stranded RNA genome composed of a large (L) and a small (S) RNA segment. The completed sequence of LCMV, presented here, reveals a formerly unknown gene (Z) on the L genomic segment. This gene is encoded in the positive or message-sense of the viral genomic RNA, whereas the adjacent gene (L) is in the genome-complementary, or negative sense. The ambisense polarity of the genes on the L RNA reiterates the polarity of genes on the small (S) genomic segment. The Z gene encodes a 10-kDa protein containing a single zinc-finger sequence (Cys2His2). A small RNA representing the message sense of the Z gene is found in infected cells and within virions. In contrast to the known LCMV proteins having structural or enzymatic functions, the predicted Z gene product is most likely to be an RNA-binding protein with a regulatory role. The encapsidation of a message sense Z RNA suggests a role for this gene immediately following virus penetration. The L/Z intergenic region is rich in cytidylic acid (C) and presents an unusual RNA structure. All cDNA clones of the intergenic region differ from each other within a certain poly(C) stretch and lack a 30-base region present in th...Continue Reading

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Citations

Mar 15, 1992·Biotechnology and Bioengineering·D A Lindsay, M J Betenbaugh
Jan 1, 1997·Journal of Virological Methods·G Bushar, J L Sagripanti
Sep 27, 2002·Antiviral Research·C C GarcíaE B Damonte
Apr 4, 2003·International Journal of Antimicrobial Agents·Cybele C GarcíaElsa B Damonte
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R LoveringP S Freemont
Mar 25, 1990·Nucleic Acids Research
Aug 15, 1994·Annals of the New York Academy of Sciences·J L Whitton
Sep 13, 2003·Journal of Virology·Rodrigo JácamoMaría T Franze-Fernández
Oct 29, 2005·Journal of Virology·Igor S LukashevichMaria S Salvato
Aug 20, 2010·Journal of Nanobiotechnology·Janice L SpeshockSaber M Hussain
Dec 4, 2012·Viruses·Nadezhda E Yun, David H Walker
Dec 4, 2012·Viruses·Sarah Katharina FehlingThomas Strecker
Jan 25, 2013·Viruses·Juan C Zapata, Maria S Salvato
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lukas FlatzDaniel D Pinschewer
Oct 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mar PerezJuan C de la Torre

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