Apr 30, 2015

The complex admixture history and recent southern origins of Siberian populations

BioRxiv : the Preprint Server for Biology
Irina PugachBrigitte Pakendorf

Abstract

Although Siberia was inhabited by modern humans at an early stage, there is still debate over whether this area remained habitable during the extremely cold period of the Last Glacial Maximum or whether it was subsequently repopulated by peoples with a recent shared ancestry. Previous studies of the genetic history of Siberian populations were hampered by the extensive admixture that appears to have taken place among these populations, since commonly used methods assume a tree-like population history and at most single admixture events. We therefore developed a new method based on the covariance of ancestry components, which we validated with simulated data, in order to investigate this potentially complex admixture history and to distinguish the effects of shared ancestry from prehistoric migrations and contact. We furthermore adapted a previously devised method of admixture dating for use with multiple events of gene flow, and applied these methods to whole-genome genotype data from over 500 individuals belonging to 20 different Siberian ethnolinguistic groups. The results of these analyses indicate that there have indeed been multiple layers of admixture detectable in most of the Siberian populations, with considerable diffe...Continue Reading

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Mentioned in this Paper

Study
Trees (plant)
Persons
Whole Genome Amplification
Cell Growth
Siberian Eskimo
Analysis
Reindeer
Migration, Cell
Genotype Determination

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