The complex between simian virus 40 T antigen and a specific host protein

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
D P Lane, L V Crawford

Abstract

The small DNA tumour virus simian virus 40 (SV40) expresses only two proteins in the cells that it has transformed, large-T and small-t. Large-T has an apparent molecular mass of 94 000 and genetic evidence indicates that it is necessary both for the induction and maintenance of the transformed state. In the lytic cycle of the virus the large-T protein acts to initiate viral DNA replication and appears to regulatea its own transcription. These properties imply that the protein must interact with existing host cell mechanisms in a specific way and that an understanding of these interactions may be important in discovering how the protein acts in 'transforming' non-permissive cells. To identify these interaction structures in the host cell an immunochemical approach has been adopted, and has shown that a fraction of the large-T protein in transformed cells exists in a specific complex with a host-coded phosphoprotein. The host protein has an apparent molecular mass of 53 000. The physiological role of this host protein-T antigen complex has been examined by studying the nature of the complex in a wide variety of different SV40 transformed cell lines. Although in SV40-transformed cells of rodent origin all the host protein present...Continue Reading

Citations

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