The complex binding of PRDM9

Genome Biology
Laure Ségurel


A recent study investigates the in vitro DNA binding behavior of PRDM9, a zinc finger protein involved in the localization of recombination hotspots in mammals.


Jan 24, 2015·Nucleic Acids Research·Michał StartekAnna Gambin
Mar 16, 2017·BMC Evolutionary Biology·Abinash PadhiLi Ma
Dec 17, 2015·Molecular Biology and Evolution·Laurie S StevisonJeffrey D Wall
Nov 30, 2020·European Journal of Human Genetics : EJHG·Shabbeer HassanSamuli Ripatti


Jul 1, 2005·Human Molecular Genetics·Alec J Jeffreys, Rita Neumann
Nov 15, 2008·Bioinformatics·Anton V PersikovMona Singh
Jul 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ingrid L BergAlec J Jeffreys
Jul 22, 2011·Nature·Anjali G HinchSimon Myers
Mar 17, 2012·Science·Adam AutonGil McVean

Related Concepts

Establishment and Maintenance of Localization
Zinc Fingers
PRDM9 gene
Recombination, Genetic
Histone-Lysine N-Methyltransferase
DNA Binding
Prdm9 protein, mouse
In Vitro [Publication Type]
DNA, Double-Stranded

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.